Amy Li

Emailamy.litorrens.eduau

Accepting PhD Students

PhD projects

1. Understanding the molecular basis of heart failure. This includes inherited forms cardiomyopathy that affects the muscles of the heart resulting in end stage heart failure.
2. Deciphering the underlying mechanisms of peripartium cardiomyopathy (PPCM). PPCM is a form of heart failure that specifically affects pregnant women.

Students interested in these areas of study will need to have some experience in bioinformatics analysis of RNAseq and proteomics datasets.

3. A study of population wide hypertension and its co-factors.
4. Population-based gene association study.

Students interested in these areas of study will need to have some experience in biostatistics and large data mining.

h-index

Research activity per year

31 Article
10 Review article
5 Editorial
4 Comment/debate
More

1 - 50 out of 55 results

2024
Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation
Wang, L., Tsakiroglou, P., Gonzales, R., Cho, S., Li, A., dos Remedios, C., Wright, N. & Kontrogianni-Konstantopoulos, A., 2024, In: JCI insight. 9, 3, e162178.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Citation (Scopus)
2023
Affimers targeting proteins in the cardiomyocyte Z-disc: Novel tools that improve imaging of heart tissue: Frontiers in Cardiovascular Medicine
Parker, F., Tang, A. A. S., Rogers, B., Carrington, G., dos Remedios, C., Li, A., Tomlinson, D. & Peckham, M., 2023, In: Frontiers in Cardiovascular Medicine. 10
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Editorial: Molecular and cellular mechanisms of heart failure: pathophysiology, pathogenesis and therapeutics
Lal, S., Campbell, K. & Li, A., 2023, In: Frontiers in Cardiovascular Medicine. 10, 1260483.
Research output: Contribution to journal › Editorial

Open Access
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Li, A., Shami, G. J., Griffiths, L., Lal, S., Irving, H. & Braet, F., 29 Sept 2023, In: Basic research in cardiology. 118, 1, p. 39 1 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
3 Citations (Scopus)
Giant mitochondria in human liver disease
Shami, G. J., Samarska, I. V., Koek, G. H., Li, A., Palma, E., Chokshi, S., Wisse, E. & Braet, F., 2023, In: Liver International.
Research output: Contribution to journal › Short survey › peer-review

Open Access
3 Citations (Scopus)
Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways
Taylor, J., Yeung, A. C. Y., Ashton, A., Faiz, A., Guryev, V., Fang, B., Lal, S., Grosser, M., dos Remedios, C. G., Braet, F., McLachlan, C. S. & Li, A., May 2023, In: Journal of Cardiovascular Development and Disease. 10, 5, 188.
Research output: Contribution to journal › Article › peer-review

Open Access
2022
A special issue of the Australian society for Biophysics
dos Remedios, C., Cranfield, C., Whelan, D., Cox, C., Shearwin, K., Ho, J., Allen, T., Shibuya, R., Hibino, E., Hayashi, K. & Li, A., 2022, In: Biophysical Reviews.
Research output: Contribution to journal › Editorial

Open Access
6 Citations (Scopus)
Models of cardiovascular surgery biobanking to facilitate translational research and precision medicine
Zhu, Y. Y., Jackson, D., Hunter, B., Beattie, L., Turner, L., Hambly, B. D., Jeremy, R. W., Malecki, C., Robertson, E. N., Li, A., dos Remedios, C., Richmond, D., Semsarian, C., O'Sullivan, J. F., Bannon, P. G. & Lal, S., Feb 2022, In: ESC Heart Failure. 9, 1, p. 21-30 10 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
5 Citations (Scopus)
Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease
Li, A., Campbell, K., Lal, S., Ge, Y., Keogh, A., Macdonald, P. S., Lau, P., Lai, J., Linke, W. A., Van der Velden, J., Field, A., Martinac, B., Grosser, M. & dos Remedios, C., 2022, In: Biophysical Reviews.
Research output: Contribution to journal › Review article › peer-review

Open Access
4 Citations (Scopus)
Resveratrol for Weight Loss in Obesity: An Assessment of Randomized Control Trial Designs in ClinicalTrials.gov
Hillsley, A., Chin, V., Li, A. & McLachlan, C. S., 1 Apr 2022, In: Nutrients. 14, 7, 1424.
Research output: Contribution to journal › Article › peer-review

Open Access
10 Citations (Scopus)
Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation
Vikhorev, P. G., Vikhoreva, N. N., Yeung, W. C., Li, A., Lal, S., Dos Remedios, C. G., Blair, C. A., Guglin, M., Campbell, K. S., Yacoub, M. H., de Tombe, P. & Marston, S. B., 7 Jan 2022, In: Cardiovascular Research. 118, 1, p. 241-253 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
18 Citations (Scopus)
2021
Announcing the call for the Special Issue on “The Australian Society for Biophysics (ASB) – 2021 Meeting”
Cranfield, C., Whelan, D., Cox, C., Shearwin, K., Ho, J., Allen, T., Shibuya, R., Hibino, E., Hayashi, K., dos Remedios, C. & Li, A., Aug 2021, In: Biophysical Reviews. 13, 4, p. 485-486 2 p.
Research output: Contribution to journal › Comment/debate

Open Access
3 Citations (Scopus)
Associations of the initial covid-19 lockdown on self-reported happiness and worry about developing loneliness: A cross-sectional analysis of rural, regional, and urban australian communities
Isaac, V., Cheng, T., Townsin, L., Assareh, H., Li, A. & McLachlan, C. S., Sept 2021, In: International Journal of Environmental Research and Public Health. 18, 18, 9501.
Research output: Contribution to journal › Article › peer-review

Open Access
11 Citations (Scopus)
Immune cell profile and immune-related gene expression of obese peripheral blood and liver tissue
Taylor, J. M., Li, A. & McLachlan, C. S., 2021, In: FEBS Letters.
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Matrix metalloproteinase-3 (MMP-3) polymorphisms are associated with prolonged ECG-derived QTc interval: A cross-sectional study of the australian rural population
Lu, Y., Ussher, N., Zhou, Y., Jelinek, H., Hambly, B., Li, A. & McLachlan, C. S., Aug 2021, In: Journal of Personalized Medicine. 11, 8, 705.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Citation (Scopus)
Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart
Hou, Y., Bai, J., Shen, X., de Langen, O., Li, A., Lal, S., dos Remedios, C. G., Baddeley, D., Ruygrok, P. N., Soeller, C. & Crossman, D. J., 8 Oct 2021, In: Frontiers in Physiology. 12, 724372.
Research output: Contribution to journal › Article › peer-review

Open Access
10 Citations (Scopus)
Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models
Daggubati, V., Hochstelter, J., Bommireddy, A., Choudhury, A., Krup, A. L., Kaur, P., Tong, P., Li, A., Xu, L., Reiter, J. F. & Raleigh, D. R., 15 Mar 2021, In: Journal of Clinical Investigation. 131, 6, e141171.
Research output: Contribution to journal › Article › peer-review

Open Access
16 Citations (Scopus)
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway
Findakly, S., Daggubati, V., Garcia, G., LaStella, S. A., Choudhury, A., Tran, C., Li, A., Tong, P., Garcia, J. Q., Puri, N., Reiter, J. F., Xu, L. & Raleigh, D. R., 4 Jan 2021, In: The Journal of cell biology. 220, 1
Research output: Contribution to journal › Article › peer-review

Open Access
17 Citations (Scopus)
2020
Biophysics of human anatomy and physiology—a Special Issue in honor of Prof. Cristobal dos Remedios on the occasion of his 80^th birthday
Hall, D., Li, A. & Cooke, R., 1 Aug 2020, In: Biophysical Reviews. 12, 4, p. 731-739 9 p.
Research output: Contribution to journal › Editorial

Open Access
5 Citations (Scopus)
Cris dos Remedios: Sydney Heart Bank and scientific mentorship beyond 2010
Li, A., 1 Aug 2020, In: Biophysical Reviews. 12, 4, p. 763-764 2 p.
Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)
Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics
Tucholski, T., Cai, W., Gregorich, Z. R., Bayne, E. F., Mitchell, S. D., McIlwain, S. J., de Lange, W. J., Wrobbel, M., Karp, H., Hite, Z., Vikhorev, P. G., Marston, S. B., Lal, S., Li, A., dos Remedios, C., Kohmoto, T., Hermsen, J., Ralphe, J. C., Kamp, T. J. & Moss, R. L. & 1 others, Ge, Y., 6 Oct 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 40, p. 24691-24700 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
65 Citations (Scopus)
Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time
Nelson, S. R., Li, A., Beck-Previs, S., Kennedy, G. G. & Warshaw, D. M., 15 Sept 2020, In: Biophysical Journal. 119, 6, p. 1050-1055 6 p.
Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus)
Lipidomics by HILIC-Ion Mobility-Mass Spectrometry
Li, A., Hines, K. M. & Xu, L., 2020, Methods in Molecular Biology. Humana Press Inc., p. 119-132 14 p. (Methods in Molecular Biology; vol. 2084).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
21 Citations (Scopus)
Nanomolar ATP binding to single myosin cross-bridges in rigor: a molecular approach to studying myosin ATP kinetics using single human cardiomyocytes
Pandzic, E., Morkel, C. A., Li, A., Cooke, R., Whan, R. M. & dos Remedios, C. G., 1 Aug 2020, In: Biophysical Reviews. 12, 4, p. 1031-1040 10 p.
Research output: Contribution to journal › Review article › peer-review
5 Citations (Scopus)
Resistome of Staphylococcus aureus in Response to Human Cathelicidin LL-37 and Its Engineered Antimicrobial Peptides
Golla, R. M., Mishra, B., Dang, X., Lakshmaiah Narayana, J., Li, A., Xu, L. & Wang, G., 10 Jul 2020, In: ACS Infectious Diseases. 6, 7, p. 1866-1881 16 p.
Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus)
2019

A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection
Li, A., Lal, S. & dos Remedios, C. G., 1 Apr 2019, In: Biophysical Reviews. 11, 2, p. 241-244 4 p.
Research output: Contribution to journal › Comment/debate

6 Citations (Scopus)
Collaborative Regulation of LRG1 by TGF-β1 and PPAR-β/δ Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis
Liu, C., Lim, S. T., Teo, M. H. Y., Tan, M. S. Y., Kulkarni, M. D., Qiu, B., Li, A., Lal, S., Dos Remedios, C. G., Tan, N. S., Wahli, W., Ferenczi, M. A., Song, W., Hong, W. & Wang, X., 1 Dec 2019, In: Circulation: Heart Failure. 12, 12, e005962.
Research output: Contribution to journal › Article › peer-review

Open Access
31 Citations (Scopus)
Pathogenesis and pathophysiology of heart failure with reduced ejection fraction: translation to human studies
Ge, Z., Li, A., McNamara, J., dos Remedios, C. & Lal, S., 15 Sept 2019, In: Heart Failure Reviews. 24, 5, p. 743-758 16 p.
Research output: Contribution to journal › Review article › peer-review
24 Citations (Scopus)
Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems
Li, A., Nelson, S. R., Rahmanseresht, S., Braet, F., Cornachione, A. S., Previs, S. B., O’Leary, T. S., McNamara, J. W., Rassier, D. E., Sadayappan, S., Previs, M. J. & Warshaw, D. M., 22 Oct 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21882-21892 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
26 Citations (Scopus)
Trials and tribulations of an early career academic pathway after returning to Australia: reflections from an early career investigator
Li, A., 1 Apr 2019, In: Biophysical Reviews. 11, 2, p. 131-134 4 p.
Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)
2018
Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease (Biophysical Reviews, (2017), 9, 4, (431-441), 10.1007/s12551-017-0305-3)
dos Remedios, C. G., Lal, S. P., Li, A., McNamara, J., Keogh, A., Macdonald, P. S., Cooke, R., Ehler, E., Knöll, R., Marston, S. B., Stelzer, J., Granzier, H., Bezzina, C., van Dijk, S., De Man, F., Stienen, G. J. M., Odeberg, J., Pontén, F., Linke, W. A. & van der Velden, J., 1 Jun 2018, In: Biophysical Reviews. 10, 3, p. 941 1 p.
Research output: Contribution to journal › Comment/debate

Open Access
Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function
Papadaki, M., Holewinski, R. J., Previs, S. B., Martin, T. G., Stachowski, M. J., Li, A., Blair, C. A., Moravec, C. S., Van Eyk, J. E., Campbell, K. S., Warshaw, D. M. & Kirk, J. A., 18 Oct 2018, In: JCI insight. 3, 20
Research output: Contribution to journal › Article › peer-review

Open Access
52 Citations (Scopus)
Editorial for issue #1 2018
dos Remedios, C. G. & Li, A., 1 Feb 2018, In: Biophysical Reviews. 10, 1
Research output: Contribution to journal › Editorial

Open Access
Erratum to: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes (Scientific Reports, (2017), 7, 1, (14829), 10.1038/s41598-017-13675-8)
Vikhorev, P. G., Smoktunowicz, N., Munster, A. B., Copeland, O. N., Kostin, S., Montgiraud, C., Messer, A. E., Toliat, M. R., Li, A., dos Remedios, C. G., Lal, S., Blair, C. A., Campbell, K. S., Guglin, M., Richter, M., Knöll, R. & Marston, S. B., 1 Dec 2018, In: Scientific Reports. 8, 1, 14485.
Research output: Contribution to journal › Comment/debate

Open Access
2 Citations (Scopus)
Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective
dos Remedios, C. G., Li, A. & Lal, S., 1 Aug 2018, In: Biophysical Reviews. 10, 4, p. 949-954 6 p.
Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)
Sarcomeric auto-oscillations in single myofibrils from the heart of patients with dilated cardiomyopathy
Kagemoto, T., Oyama, K., Yamane, M., Tsukamoto, S., Kobirumaki-Shimozawa, F., Li, A., Dos Remedios, C., Fukuda, N. & Ishiwata, S., 1 Jul 2018, In: Circulation: Heart Failure. 11, 7, e004333.
Research output: Contribution to journal › Article › peer-review

Open Access
9 Citations (Scopus)
Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca²⁺-dependent manner
Lin, B. L., Li, A., Mun, J. Y., Previs, M. J., Previs, S. B., Campbell, S. G., Dos Remedios, C. G., De Tombe, P. P., Craig, R., Warshaw, D. M. & Sadayappan, S., 1 Dec 2018, In: Scientific Reports. 8, 1, 2604.
Research output: Contribution to journal › Article › peer-review

Open Access
31 Citations (Scopus)
2017
Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes
Vikhorev, P. G., Smoktunowicz, N., Munster, A. B., Copeland, O., Kostin, S., Montgiraud, C., Messer, A. E., Toliat, M. R., Li, A., Dos Remedios, C. G., Lal, S., Blair, C. A., Campbell, K. S., Guglin, M., Knoll, R. & Marston, S. B., 1 Dec 2017, In: Scientific Reports. 7, 1, 14829.
Research output: Contribution to journal › Article › peer-review

Open Access
34 Citations (Scopus)
Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium
Mamidi, R., Li, J., Gresham, K. S., Verma, S., Doh, C. Y., Li, A., Lal, S., Dos Remedios, C. G. & Stelzer, J. E., 1 Oct 2017, In: Circulation: Heart Failure. 10, 10, e004257.
Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus)
Increased collagen within the transverse tubules in human heart failure
Crossman, D. J., Shen, X., Jüllig, M., Munro, M., Hou, Y., Middleditch, M., Shrestha, D., Li, A., Lal, S., Dos Remedios, C. G., Baddeley, D., Ruygrok, P. N. & Soeller, C., 1 Jul 2017, In: Cardiovascular Research. 113, 8, p. 879-891 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
50 Citations (Scopus)
MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., Van Der Velden, J., Ackerman, M. J., Cooke, R. & Dos Remedios, C. G., Jun 2017, In: PLoS ONE. 12, 6, e0180064.
Research output: Contribution to journal › Article › peer-review

Open Access
99 Citations (Scopus)
Special issue on titin and its binding proteins in striated muscle
Li, A. & dos Remedios, C., 1 Jun 2017, In: Biophysical Reviews. 9, 3, p. 177-178 2 p.
Research output: Contribution to journal › Editorial

Open Access

1 Citation (Scopus)
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease
dos Remedios, C. G., Lal, S. P., Li, A., McNamara, J., Keogh, A., Macdonald, P. S., Cooke, R., Ehler, E., Knöll, R., Marston, S. B., Stelzer, J., Granzier, H., Bezzina, C., van Dijk, S., De Man, F., Stienen, G. J. M., Odeberg, J., Pontén, F., Linke, W. & van der Velden, J., 1 Aug 2017, In: Biophysical Reviews. 9, 4, p. 431-441 11 p.
Research output: Contribution to journal › Review article › peer-review
34 Citations (Scopus)
2016
Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes
McNamara, J. W., Li, A., Smith, N. J., Lal, S., Graham, R. M., Kooiker, K. B., van Dijk, S. J., Remedios, C. G. D., Harris, S. P. & Cooke, R., 1 May 2016, In: Journal of Molecular and Cellular Cardiology. 94, p. 65-71 7 p.
Research output: Contribution to journal › Article › peer-review
102 Citations (Scopus)
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
Lin, Z., Guo, H., Cao, Y., Zohrabian, S., Zhou, P., Ma, Q., VanDusen, N., Guo, Y., Zhang, J., Stevens, S. M., Liang, F., Quan, Q., van Gorp, P. R., Li, A., dos Remedios, C., He, A., Bezzerides, V. J. & Pu, W. T., 21 Nov 2016, In: Developmental Cell. 39, 4, p. 466-479 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
86 Citations (Scopus)
Limitations in Translating Animal Studies to Humans in Cardiovascular Disease
Lal, S., Li, A. & dos Remedios, C., 1 Apr 2016, In: Journal of Cardiovascular Translational Research. 9, 2, p. 165-166 2 p.
Research output: Contribution to journal › Letter

14 Citations (Scopus)
Tissue microarray profiling in human heart failure
Lal, S., Nguyen, L., Tezone, R., Ponten, F., Odeberg, J., Li, A. & dos Remedios, C., 1 Sept 2016, In: Proteomics. 16, 17, p. 2319-2326 8 p.
Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)
2015
Best practice BioBanking of human heart tissue
Lal, S., Li, A., Allen, D., Allen, P. D., Bannon, P., Cartmill, T., Cooke, R., Farnsworth, A., Keogh, A. & dos Remedios, C., 1 Dec 2015, In: Biophysical Reviews. 7, 4, p. 399-406 8 p.
Research output: Contribution to journal › Review article › peer-review
30 Citations (Scopus)
Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C
Mamidi, R., Gresham, K. S., Li, A., dos Remedios, C. G. & Stelzer, J. E., 1 Aug 2015, In: Journal of Molecular and Cellular Cardiology. 85, p. 262-272 11 p.
Research output: Contribution to journal › Article › peer-review
43 Citations (Scopus)
Special Issue on human heart failure
Li, A. & dos Remedios, C. G., Mar 2015, In: Biophysical Reviews. 7, 1
Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Amy Li

Research output

Search results