Personal profile
Research interests
Bioinformatics with a focus on public domain cardiac, cancer and neuroscience genetics and statistical programming in R and Bioconductor and performing statistical analysis of large data sets using various methods including machine learning, meta-analysis and single cell sequence analysis. I am currently contributing to bioinformatics research using big data at the Centre for Healthy Futures (CHEF) with a focus on digital pathology and identifying disease specific cell types and biochemical pathways.
Research Profile
I have a PhD from the University of Sydney, using animal models for translational understanding of Multiple sclerosis and autoimmune demyelinating diseases. I also have industry experience having worked with GSK drug discovery in China for neuroscience targeted therapies and have experience in infectious disease research, cardiovascular disease, oncology, neuroscience and immunology from my other post-doctoral positions in Australia, Singapore and China. I have more than 20 years of general academic research experience and some industry experience to draw on providing a very broad range of expertise across disciplines to inform my current research focus in bioinformatics using genetic datasets for cardiac disease, cancer, Multiple Sclerosis and Epilepsy. The majority research I have published provides evidence for the cellular and molecular basis of disease using models and clinical research data. Previous sponsors of my research include the Multiple Sclerosis Society of Australia, The National Heart Foundation, ASTAR in Singapore and higher education funding in China.
Education/Academic qualification
Immunology, PhD, B cell and T cell Effector Mechanisms in Experimental Autoimmune Neuritis
Award Date: 19 Dec 2000
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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The molecular and cellular landscape of hypertrophic cardiomyopathy phenotypes: transition from obstructive to end-stage heart failure
Taylor, J., Lal, S., Braet, F., McLachlan, C. S. & Li, A., 7 Jan 2025, In: Journal of Molecular Medicine.Research output: Contribution to journal › Article › peer-review
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Transcriptional meta-analysis and immune cell profiles reveal altered neutrophil dynamics in chronic atrial fibrillation
Stone, E., Taylor, J., Li, A. & McLachlan, C. S., 5 Mar 2025, In: Royal Society Open Science. 12, 3, 241102.Research output: Contribution to journal › Article › peer-review
Open Access -
Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways
Taylor, J., Yeung, A. C. Y., Ashton, A., Faiz, A., Guryev, V., Fang, B., Lal, S., Grosser, M., dos Remedios, C. G., Braet, F., McLachlan, C. S. & Li, A., May 2023, In: Journal of Cardiovascular Development and Disease. 10, 5, 188.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Citations (Scopus) -
Immune cell profile and immune-related gene expression of obese peripheral blood and liver tissue
Taylor, J. M., Li, A. & McLachlan, C. S., 2021, In: FEBS Letters.Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Scopus) -
MACHINE LEARNING BASED DECONVOLUTION OF MICROARRAY ATRIAL SAMPLES FROM ATRIAL FIBRILLATION PATIENTS REVEALS INCREASED FRACTIONS OF FOLLICULAR CD4+ T LYMPHOCYTES AND GAMMA-DELTA T CELLS
Stone, E., Taylor, J., Kiat, H. & McLachlan, C. S., Dec 2021, In: Journal of Physiology and Pharmacology. 72, 6, p. 957-963 7 p.Research output: Contribution to journal › Article › peer-review
8 Link opens in a new tab Citations (Scopus)