Stimulation of the cardiac Na+-K+ pump in heart failure

Project Details


Heart failure is a debilitating condition characterised by a decreased heart pump function. Raised Na+ levels and increased oxidative stress in cardiac cells are important in its causation. While traditional antioxidants are not useful in treatment, we have found that a group of drugs designed to induce weight loss can reverse oxidative inhibition of the mechanism that pumps Na+ out of heart cells. The effect of these drugs on the Na+ pumping mechanism and heart failure will be examined.

Funded AUD 533,541.03
Short titleStimulation of the cardiac Na+-K+ pump in heart failure
Effective start/end date1/01/1031/03/13


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