Case reports provide a valuable insight into osteopathic practice. They allow for the description of diagnoses, interventions and management strategies for complaints that present to practice. Although case reports are traditionally associated with descriptions of rare or unique cases, reports of more common presentations to osteopaths are exceptionally useful. The purpose of this Masterclass is to describe how to construct a case report for the journal, and many other medical journals. The Masterclass outlines how to use the Case Report (CARE) guidelines and provides examples from published case reports related to osteopathic practice. We hope that this Masterclass will encourage practitioners to consider publishing case reports to expand the professions’ evidence base and inform future research.