Abnormal myelination in the spinal cord of PTPα-knockout mice

Quan Hong Ma, Tao Xiang, Zara Zhuyun Yang, Xu Zhang, Jude Taylor, Zhi Cheng Xiao

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

PTPα interacts with F3/contactin to form a membrane-spanning co-receptor complex to transduce extracellular signals to Fyn tyrosine kinase. As both F3 and Fyn regulate myelination, we investigated a role for PTPα in this process. Here, we report that both oligodendrocytes and neurons express PTPα that evenly distributes along myelinated axons of the spinal cord. The ablation of PTPα in vivo leads to early formation of transverse bands that are mainly constituted by F3 and Caspr along the axoglial interface. Notably, PTPα deficiency facilitates abnormal myelination and pronouncedly increases the number of non-landed oligodendrocyte loops at shortened paranodes in the spinal cord. Small axons, which are normally less myelinated, have thick myelin sheaths in the spinal cord of PTPα-null animals. Thus, PTPα may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalCell Adhesion and Migration
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Keywords

  • Axon
  • Caspr
  • F3/contactin
  • Myelination
  • PTPα

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