TY - JOUR
T1 - Acute coronary ligation in the dog induces time-dependent transitional changes in mitochondrial crista in the non-ischaemic ventricular myocardium
AU - McLachlan, Craig Steven
AU - Almsherqi, Zakaria A.
AU - Chua, Kerin Sze Yi
AU - Liew, Yu Ying
AU - Low, Chwee Wah
AU - Deng, Yuru
PY - 2007/3/1
Y1 - 2007/3/1
N2 - 1. The aim of the present study was to examine, in the dog myocardium, the incidence of zig-zag mitochondrial cristae over time in the non-ischaemic posterior wall, following an acute anterior wall infarct. 2. Changes within the myocardial mitochondrial crista membrane in dogs were investigated following acute left anterior descending coronary artery ligation. Transmyocardial biopsy samples were taken serially from the posterior non-ischaemic wall in the same dog. 3. Changes in heart mitochondrial cristae were examined by transmission electron microscopy prior to coronary ligation (control) and 40 min and 2, 4, 6 and 24 h postinfarction. In control hearts, 90% of mitochondrial cristae had a lamelliform appearance. Following infarction, there were twotransitional states with respect to mitochondrial cristae, the first characterized by undulating lamelliform cristae that are also found in 10% of control samples and a second transitional state that was zig-zag and reached a maximum between 6 and 24 h after infarction. 4. In conclusion, an undulating lamelliform crista pattern is present in the non-ischaemic wall of the acute infarcted dog and we hypothesize that this may be an intermediate from, between 'normal' lamelliform and 'abnormal' zig-zag cristae.
AB - 1. The aim of the present study was to examine, in the dog myocardium, the incidence of zig-zag mitochondrial cristae over time in the non-ischaemic posterior wall, following an acute anterior wall infarct. 2. Changes within the myocardial mitochondrial crista membrane in dogs were investigated following acute left anterior descending coronary artery ligation. Transmyocardial biopsy samples were taken serially from the posterior non-ischaemic wall in the same dog. 3. Changes in heart mitochondrial cristae were examined by transmission electron microscopy prior to coronary ligation (control) and 40 min and 2, 4, 6 and 24 h postinfarction. In control hearts, 90% of mitochondrial cristae had a lamelliform appearance. Following infarction, there were twotransitional states with respect to mitochondrial cristae, the first characterized by undulating lamelliform cristae that are also found in 10% of control samples and a second transitional state that was zig-zag and reached a maximum between 6 and 24 h after infarction. 4. In conclusion, an undulating lamelliform crista pattern is present in the non-ischaemic wall of the acute infarcted dog and we hypothesize that this may be an intermediate from, between 'normal' lamelliform and 'abnormal' zig-zag cristae.
KW - Mitochondrial cristae
KW - Remote myocardial ventricular non-ischaemic area
KW - Undulating lamelliform
KW - Zig-zag
UR - http://www.scopus.com/inward/record.url?scp=33846457340&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1681.2007.04537.x
DO - 10.1111/j.1440-1681.2007.04537.x
M3 - Article
C2 - 17250647
AN - SCOPUS:33846457340
VL - 34
SP - 250
EP - 253
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
SN - 0305-1870
IS - 3
ER -