Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function

Chun Ming Wang, Zakaria A. Almsherqi, Craig S. McLachlan, Slade Matthews, Malarmathy Ramachandran, Stacey Kh Tay, Yuru Deng

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4 Citations (Scopus)


Associations between uncoupling protein (UCP) expression and functional changes in myocardial mitochondrial bio-energetics have not been well studied during periods of starvation stress. Our aim was to study the effects of acute starvation, for 24 or 48 h, on combined cardiac mitochondrial function and UCP expression in mice. Isolated heart mitochondria from female mice starved for 48 h compared to that from mice fed revealed a significantly (p < 0.05) decreased adenosine diphosphate-to-oxygen ratio, a significantly increased proton leak and an increased GTP inhibition on palmitic acid-induced state 4 oxygen consumption (p < 0.05). These bio-energetic functional changes were associated with increases in mitochondrial UCP2 and UCP3 protein expression. In conclusion, our findings suggest that increased UCP2 and UCP3 levels may contribute to decreased myocardial mitochondrial bio-energetic function due to starvation.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
Issue number1
Publication statusPublished - 1 Jan 2011
Externally publishedYes



  • Cardiac myocytes
  • mitochondrial bio-energetics
  • oxidative stress
  • starvation
  • uncoupling protein

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