Alternatives to bodyweight for estimating the dose of praziquantel needed to treat schistosomiasis

Andrew Hall; Catherine Nokes; Su Tung Wen; Sam Adjei; Charles Kihamia; Lillian Mwanri; Emily Bobrow; Joseph De Graft-Johnson; Don Bundy

doi:10.1016/S0035-9203(99)90087-1

Alternatives to bodyweight for estimating the dose of praziquantel needed to treat schistosomiasis

Andrew Hall, Catherine Nokes, Su Tung Wen, Sam Adjei, Charles Kihamia, Lillian Mwanri, Emily Bobrow, Joseph De Graft-Johnson, Don Bundy

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Data on age, height and mid upper-arm circumference (MUAC) from nearly 6000 schoolchildren in Ghana, Tanzania and Malawi (not MUAC) were used to examine their power to predict bodyweight, and thus the dosage of praziquantel required to treat schistosomiasis. Height was found to provide a simple and reasonably accurate estimate of weight, and about 75% of children would have been given a dosage of praziquantel within the range normally given using bodyweight at a dosage of 40 mg/kg bodyweight. The upper and lower ranges in dosage did not exceed dosages of praziquantel which have been used before or are currently recommended to treat schistosomiasis. A pole marked with the number of tablets could thus be used as a simple way to determine the dose of praziquantel to treat children in school-based health programmes.

Original language	English
Pages (from-to)	653-658
Number of pages	6
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	93
Issue number	6
DOIs	https://doi.org/10.1016/S0035-9203(99)90087-1
Publication status	Published - 1999
Externally published	Yes

Keywords

Dosage determination
Ghana
Malawi
Praziquantel
Schistosoma haematobium chemotherapy
Schistosoma mansoni
Schistosomiasis
School health programmes
Tanzania

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10.1016/S0035-9203(99)90087-1

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title = "Alternatives to bodyweight for estimating the dose of praziquantel needed to treat schistosomiasis",

abstract = "Data on age, height and mid upper-arm circumference (MUAC) from nearly 6000 schoolchildren in Ghana, Tanzania and Malawi (not MUAC) were used to examine their power to predict bodyweight, and thus the dosage of praziquantel required to treat schistosomiasis. Height was found to provide a simple and reasonably accurate estimate of weight, and about 75% of children would have been given a dosage of praziquantel within the range normally given using bodyweight at a dosage of 40 mg/kg bodyweight. The upper and lower ranges in dosage did not exceed dosages of praziquantel which have been used before or are currently recommended to treat schistosomiasis. A pole marked with the number of tablets could thus be used as a simple way to determine the dose of praziquantel to treat children in school-based health programmes.",

keywords = "Dosage determination, Ghana, Malawi, Praziquantel, Schistosoma haematobium chemotherapy, Schistosoma mansoni, Schistosomiasis, School health programmes, Tanzania",

author = "Andrew Hall and Catherine Nokes and Wen, {Su Tung} and Sam Adjei and Charles Kihamia and Lillian Mwanri and Emily Bobrow and {De Graft-Johnson}, Joseph and Don Bundy",

note = "Funding Information: Acknowledgements The Partnership for Child Development programmes in Ghana and Tanzania are supported by the Edna McConnell Clark Foundation. The Partnership receives support from the UNDP, the Rockefeller Foundation, the James S. McDonnell Foundation, the WHO, the Wellcome Trust and the World Bank. The Save the Children Federation programme in Malawi is supported by a private donor.",

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AU - Kihamia, Charles

AU - Mwanri, Lillian

AU - Bobrow, Emily

AU - De Graft-Johnson, Joseph

AU - Bundy, Don

N1 - Funding Information: Acknowledgements The Partnership for Child Development programmes in Ghana and Tanzania are supported by the Edna McConnell Clark Foundation. The Partnership receives support from the UNDP, the Rockefeller Foundation, the James S. McDonnell Foundation, the WHO, the Wellcome Trust and the World Bank. The Save the Children Federation programme in Malawi is supported by a private donor.

PY - 1999

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AB - Data on age, height and mid upper-arm circumference (MUAC) from nearly 6000 schoolchildren in Ghana, Tanzania and Malawi (not MUAC) were used to examine their power to predict bodyweight, and thus the dosage of praziquantel required to treat schistosomiasis. Height was found to provide a simple and reasonably accurate estimate of weight, and about 75% of children would have been given a dosage of praziquantel within the range normally given using bodyweight at a dosage of 40 mg/kg bodyweight. The upper and lower ranges in dosage did not exceed dosages of praziquantel which have been used before or are currently recommended to treat schistosomiasis. A pole marked with the number of tablets could thus be used as a simple way to determine the dose of praziquantel to treat children in school-based health programmes.

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Alternatives to bodyweight for estimating the dose of praziquantel needed to treat schistosomiasis

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Keywords

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