An association of serum ALT with elevated blood pressure in senior adults: a case-control study

Xiuqin Hong, Nualnong Wongtongkam, Paul Russell Ward, Shuiyuan Xiao, Shuling Wang, Qian Peng, Qi Zuo, Dan Zeng, Jia Wang, Chenxu Wang, Jian Chen, Na Zhang

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Hypertension is a major risk factor for cardiovascular diseases in China; hence, identifying good serum markers might provide cost benefits in terms of reducing morbidity rates. In this population-based case-control study, participants were recruited from five districts in Hunan province, and 416 cases were matched with an equal number of controls. Markers related to elevated blood pressure were assessed: Body Mass Index, total cholesterol, triglycerides, fasting blood glucose, and creatinine. Three potential serum markers homocysteine (HCY), C-reactive protein (CRP), and alanine aminotransferase (ALT) were dichotomized as normal or high level. Binary logistic regression was used to determine odds ratios (ORs) and 95% confidence intervals (CIs). The findings showed that ALT is a powerful serum marker for predicting high risk of high blood pressure with OR = 2.94, 95% CI (1.44–6.02), while there were no significant differences between cases and controls for HCY and CRP. Additionally, it seems likely that high concentrations of HCY conferred a protective effect against elevated blood pressure. When adjusted for sex, ORs for hypertensive females were nearly five times higher than for hypertensive males (OR = 4.34, 95% CI = 1.17–16.04). The study strongly supports findings showing ALT is a potential indicator for patients with hypertension.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalClinical and Experimental Hypertension
Issue number8
Publication statusPublished - 16 Nov 2016
Externally publishedYes


  • Alanine aminotransferase
  • biomarkers
  • China
  • elderly
  • hypertension


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