An introduction to glutamine metabolism

Vinicius Fernandes Cruzat, Philip Newsholme

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Hlaziwetz and Habermann rst described glutamine as a molecule with biologically important properties in 1873. They suggested that the presence of ammonia (as NH4+), detected following hydrolysis of proteins, arose by degradation linked to amide groups from glutamine and asparagine (Mora 2012). About 10 years later, Schulze and Bosshard isolated glutamine from a natural source (beet juice), and Damodaran and his collaborators contributed to the rst description of glutamine metabolism. However, the number of studies investigating glutamine metabolism and links to intermediary metabolism increased following the early work of Sir Hans Adolf Krebs (1900-1981), who was responsible for some of the most important discoveries in metabolic biochemistry and physiology in the twentieth century (Nobel Prize in Physiology or Medicine in 1953).

Original languageEnglish
Title of host publicationGlutamine
Subtitle of host publicationBiochemistry, Physiology, and Clinical Applications
PublisherCRC Press
Number of pages15
ISBN (Electronic)9781482234305
ISBN (Print)9781482234299
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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    Cruzat, V. F., & Newsholme, P. (2017). An introduction to glutamine metabolism. In Glutamine: Biochemistry, Physiology, and Clinical Applications (pp. 3-17). CRC Press.