Association of aortic stenosis with platelet hyperaggregability and impaired responsiveness to nitric oxide

Yuliy Y. Chirkov, Andrew S. Holmes, Scott R. Willoughby, Simon Stewart, John D. Horowitz

Research output: Contribution to journalArticle

32 Citations (Scopus)


In summary, the present study demonstrates that AS, irrespective of the presence and/or absence of CAD, is associated with platelet hyperaggregability and hyporesponsiveness to antiaggregatory effects of NO donor SNP. Treatment with the prophylactic antianginal agent perhexiline improves platelet responsiveness to NO.

Original languageEnglish
Pages (from-to)551-554
Number of pages4
JournalAmerican Journal of Cardiology
Issue number5
Publication statusPublished - 1 Sep 2002
Externally publishedYes


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