Auditory event-related P300 potentials in rheumatoid arthritis patients

S. Tomasevic-Todorovic, K. Boskovic, D. Filipovic, B. Milekic, M. Grajic, F. Hanna

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the study was to assess P300 event-related potentials (ERPs) in patients suffering from rheumatoid arthritis (RA) in relation to the duration of illness, degree of disease activity, anatomical and functional stage of the disease, pain intensity, and pain unpleasantness. The cross-sectional study included 53 women with RA (RA group; mean age 50.58 ± 0.93 years) and 27 healthy women (control group, C; 49.41 ± 1.08 years). The intensity and unpleasantness of pain were determined using a visual analog scale (VAS); the functional status was assessed using HAQ (Health Assessment Questionnaire), and the disease activity was estimated using the disease activity scale (DAS28). The P300 waves initiated by auditory stimulations according to the oddball paradigm were recorded from leads Fz and Cz. There were no significant differences between the P300 latencies in both leads. At the same time, the average P300 amplitudes in both leads were found to be considerably lower (P < 0.05) in the RA group compared to the C group. Thus, there is a statistically significant amplitude difference between the P300 cognitive ERPs in RA patients and control subjects.

Original languageEnglish
Article numberA008
Pages (from-to)138-143
Number of pages6
JournalNeurophysiology
Volume47
Issue number2
DOIs
Publication statusPublished - 26 Jun 2015
Externally publishedYes

    Fingerprint

Keywords

  • P300 event-related potentials (ERPs)
  • Pain intensity
  • Pain unpleasantness
  • Rheumatoid arthritis
  • Visual analog scale (VAS)

Cite this

Tomasevic-Todorovic, S., Boskovic, K., Filipovic, D., Milekic, B., Grajic, M., & Hanna, F. (2015). Auditory event-related P300 potentials in rheumatoid arthritis patients. Neurophysiology, 47(2), 138-143. [A008]. https://doi.org/10.1007/s11062-015-9510-5