Chronic Phenobarbital-Induced Mitochondrial Pleomorphism in the Rat Liver

Zakaria Almsherqi, Craig Steven Mclachlan, Stacey K.H. Tay, Yuru Deng

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.

Original languageEnglish
Pages (from-to)833-835
Number of pages3
JournalToxicologic Pathology
Issue number6
Publication statusPublished - 2007
Externally publishedYes


  • electron microscopy
  • liver
  • Mitochondria
  • phenobarbital
  • rat
  • ultrastructure


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