Chronic phenobarbital-induced mitochondrial pleomorphism in the rat liver.

Zakaria Almsherqi, Craig Steven McLachlan, Stacey K.H. Tay, Yuru Deng

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Abstract

Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.

Original languageEnglish
Pages (from-to)833-835
Number of pages3
JournalToxicologic Pathology
Volume35
Issue number6
DOIs
Publication statusPublished - 2007
Externally publishedYes

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