Abstract
Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.
Original language | English |
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Pages (from-to) | 833-835 |
Number of pages | 3 |
Journal | Toxicologic Pathology |
Volume | 35 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2007 |
Externally published | Yes |
Keywords
- electron microscopy
- liver
- Mitochondria
- phenobarbital
- rat
- ultrastructure