Chronic Phenobarbital-Induced Mitochondrial Pleomorphism in the Rat Liver

Zakaria Almsherqi; Craig Steven Mclachlan; Stacey K.H. Tay; Yuru Deng

doi:10.1080/01926230701584171

Chronic Phenobarbital-Induced Mitochondrial Pleomorphism in the Rat Liver

Zakaria Almsherqi, Craig Steven Mclachlan, Stacey K.H. Tay, Yuru Deng

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.

Original language	English
Pages (from-to)	833-835
Number of pages	3
Journal	Toxicologic Pathology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1080/01926230701584171 https://doi.org/10.1080/01926230701584171
Publication status	Published - 2007
Externally published	Yes

Keywords

electron microscopy
liver
Mitochondria
phenobarbital
rat
ultrastructure

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10.1080/01926230701584171Licence: CC BY
10.1080/01926230701584171

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title = "Chronic Phenobarbital-Induced Mitochondrial Pleomorphism in the Rat Liver",

abstract = "Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.",

keywords = "electron microscopy, liver, Mitochondria, phenobarbital, rat, ultrastructure",

author = "Zakaria Almsherqi and Mclachlan, {Craig Steven} and Tay, {Stacey K.H.} and Yuru Deng",

year = "2007",

doi = "10.1080/01926230701584171",

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AU - Almsherqi, Zakaria

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AU - Tay, Stacey K.H.

AU - Deng, Yuru

PY - 2007

Y1 - 2007

N2 - Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.

AB - Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.

KW - electron microscopy

KW - liver

KW - Mitochondria

KW - phenobarbital

KW - rat

KW - ultrastructure

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JO - Toxicologic Pathology

JF - Toxicologic Pathology

SN - 0192-6233

IS - 6

ER -

Chronic Phenobarbital-Induced Mitochondrial Pleomorphism in the Rat Liver

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Keywords

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