Abstract
Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.
| Original language | English |
|---|---|
| Pages (from-to) | 833-835 |
| Number of pages | 3 |
| Journal | Toxicologic Pathology |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2007 |
| Externally published | Yes |
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Almsherqi, Z., McLachlan, C. S., Tay, S. K. H., & Deng, Y. (2007). Chronic phenobarbital-induced mitochondrial pleomorphism in the rat liver. Toxicologic Pathology, 35(6), 833-835. https://doi.org/10.1080/01926230701584171