Delay in opening the infarct related coronary artery increases plasma atrial natriuretic peptide levels

Craig S. McLachlan, Jianlin Yin, Catherine Driussi, Adam J. Landau, Xavier Chaufour, Geoffery White, Brett Hambly, Mark A. McGuire

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Abstract

Plasma atrial natriuretic peptide (ANP) levels were measured in rabbits during the late healing phase of myocardial infarcts. Significant differences in plasma ANP levels (P<0.02) were found between rabbits that had undergone very late (6 h) or early reperfusion (20 and 45 min of ischemia) of the infarct related coronary artery. Differences in ANP levels were independent of infarct size, ventricular remodeling and infarct expansion. We conclude late reperfusion of infarct related artery, independent of myocardial salvage, is associated with increased circulating ANP plasma levels.

Original languageEnglish
Pages (from-to)R3
JournalEuropean Journal of Pharmacology
Volume379
Issue number1
DOIs
Publication statusPublished - 20 Aug 1999
Externally publishedYes

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Keywords

  • ANP atrial natriuretic peptide
  • Myocardial infarction
  • Reperfusion, late

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