Differences in anxiety-related behavior between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice

C. S. McLachlan, C. Yi Xing Soh

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7 Citations (Scopus)


The influence of ApoE gene deletion on the anxiety state has not been previously investigated. The elevated plus maze was used in this study to determine differences in anxiety-related behavior between apoE-deficient and wild type C57BL/6 mice. The apoE-deficient mice demonstrated less anxiety on the elevated plus maze by spending more time in the open arms of the elevated plus maze compared to wild type mice (p<0.001). Additionally, female apoE-deficient mice visited the open arm of the maze more often than their apoE-deficient male counterpart (p<0.05). The anxiety state and/or sex are possible variables to be considered when designing physiological and/or behavioral studies involving mice that are apoE-deficient.

Original languageEnglish
Pages (from-to)701-704
Number of pages4
JournalPhysiological Research
Issue number6
Publication statusPublished - 1 Dec 2005
Externally publishedYes



  • Anxiety
  • Apolipoprotein E
  • Elevated plus maze
  • Mice

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