ObjectivesMenopause is a natural part of women?s lives and is associated with a series of complications that can impair their quality of life. This study was conducted to determine the effect of specific educational interventions on the quality of life among postmenopausal women.MethodsThis randomized controlled trial was conducted on 80 menopausal women who met the inclusion and exclusion criteria and were selected through the multi-stage stratified random sampling method. The participants were randomly allocated to either the control or intervention group (40 per group). The intervention comprised 5 ? 45-min educational sessions based on the Multi-Theory Model on the predetermined days of the week. The scores of the quality of life level were collected at baseline, immediately, and 3 months after the intervention using the Menopause-Specific Quality of Life questionnaire (MENQOL). The control group received a health advice.ResultsAnalysis of variance of repeated measures showed a significant interaction between time and intervention. The comparison between the mean score of quality of life of the ?before,? ?immediately after intervention,? and ?3 months after the intervention? showed a significant difference between the two groups. The intervention group quality of life improved significantly as the intervention went on compared to the control group.ConclusionStructured simple educational programs based on the Multi-Theory Model could be used as a simple and noninvasive intervention that help menopausal women improve their quality of life through menopausal symptoms relief. Further interventions with larger trials may be required to confirm these findings.