TY - JOUR
T1 - Effects of dietary restriction or swimming on lymphocytes and macrophages functionality from old rats
AU - Meneguello-Coutinho, Marcela
AU - Caperuto, Erico
AU - Bacurau, Aline Villa Nova
AU - Chamusca, Grabriela
AU - Uchida, Marco Carlos
AU - Tibana, Ramires Alsamir
AU - Pereira, Guilherme Borges
AU - Navalta, James Wilfred
AU - Wasinski, Frederick
AU - Cavaglieri, Claudia Regina
AU - Prestes, Jonato
AU - Costa Rosa, Luis Fernando Bicudo Pereira
AU - Bacurau, Reury Frank
PY - 2014
Y1 - 2014
N2 - Although aging compromises the functionality of macrophages (MΦ) and lymphocytes (LY), and dietary restriction (DR) and exercise partially counterbalance immunosenescence, it is unknown what effects of both strategies have on the functionality of these immune cells. Rats were randomly distributed into adult control (AD), older group (OLD), older submitted to 50% of DR (DR) and older submitted to swimming (EX) (n = 10 in each group). The function of immune cells (proliferative index, phagocytic capacity and H2O2 production), the weight and protein content of lymphoid organs (thymus and spleen), plasma glutamine concentration, interleukins (IL-1, IL-2, IL-6) and, immunoglobulins (IgA and IgG) were analysed. There was an increase of 74% in body weight in aged animals as compared with the AD group, while body weight reduced 19% in the DR as compared with the OLD group. Swimming training stimulated MΦ phagocytosis, while the EX group presented a decrease of the proliferative capacity of LY from the mesenteric lymph nodes (44% and 62%, respectively), when stimulated with ConA and LPS as compared with the old rats. These data demonstrated that DR and exercise affects differentially MΦ and LY function.
AB - Although aging compromises the functionality of macrophages (MΦ) and lymphocytes (LY), and dietary restriction (DR) and exercise partially counterbalance immunosenescence, it is unknown what effects of both strategies have on the functionality of these immune cells. Rats were randomly distributed into adult control (AD), older group (OLD), older submitted to 50% of DR (DR) and older submitted to swimming (EX) (n = 10 in each group). The function of immune cells (proliferative index, phagocytic capacity and H2O2 production), the weight and protein content of lymphoid organs (thymus and spleen), plasma glutamine concentration, interleukins (IL-1, IL-2, IL-6) and, immunoglobulins (IgA and IgG) were analysed. There was an increase of 74% in body weight in aged animals as compared with the AD group, while body weight reduced 19% in the DR as compared with the OLD group. Swimming training stimulated MΦ phagocytosis, while the EX group presented a decrease of the proliferative capacity of LY from the mesenteric lymph nodes (44% and 62%, respectively), when stimulated with ConA and LPS as compared with the old rats. These data demonstrated that DR and exercise affects differentially MΦ and LY function.
KW - Aging
KW - Caloric restriction
KW - Cell function
KW - Exercise
KW - Immune system
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=84893341632&partnerID=8YFLogxK
U2 - 10.3109/08820139.2013.847456
DO - 10.3109/08820139.2013.847456
M3 - Article
C2 - 24206426
AN - SCOPUS:84893341632
SN - 0882-0139
VL - 43
SP - 113
EP - 122
JO - Immunological Investigations
JF - Immunological Investigations
IS - 2
ER -
