TY - JOUR
T1 - Giant mitochondria in cardiomyocytes
T2 - cellular architecture in health and disease
AU - Li, Amy
AU - Shami, Gerald J.
AU - Griffiths, Lisa
AU - Lal, Sean
AU - Irving, Helen
AU - Braet, Filip
N1 - Publisher Copyright:
© 2023. Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/9/29
Y1 - 2023/9/29
N2 - Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and exercise, and clinically in alcohol-induced heart disease and various cardiomyopathies. This mitochondrial aberration is widely considered an early structural hallmark of disease leading to adverse organ function. In this thematic paper, we discuss the current state-of-knowledge on the presence, structure and functional implications of giant mitochondria in heart muscle. Despite its demonstrated reoccurrence in different heart diseases, the literature on this pathophysiological phenomenon remains relatively sparse since its initial observations in the early 60s. We review historical and contemporary investigations from cultured cardiomyocytes to human tissue samples to address the role of giant mitochondria in cardiac health and disease. Finally, we discuss their significance for the future development of novel mitochondria-targeted therapies to improve cardiac metabolism and functionality.
AB - Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and exercise, and clinically in alcohol-induced heart disease and various cardiomyopathies. This mitochondrial aberration is widely considered an early structural hallmark of disease leading to adverse organ function. In this thematic paper, we discuss the current state-of-knowledge on the presence, structure and functional implications of giant mitochondria in heart muscle. Despite its demonstrated reoccurrence in different heart diseases, the literature on this pathophysiological phenomenon remains relatively sparse since its initial observations in the early 60s. We review historical and contemporary investigations from cultured cardiomyocytes to human tissue samples to address the role of giant mitochondria in cardiac health and disease. Finally, we discuss their significance for the future development of novel mitochondria-targeted therapies to improve cardiac metabolism and functionality.
KW - Cardiomyopathy
KW - Giant and megamitochondria
KW - Histopathological marker
KW - Mitochondrial aberrations
KW - Mitochondrion pathophysiology
KW - Muscle disease
UR - http://www.scopus.com/inward/record.url?scp=85172824972&partnerID=8YFLogxK
U2 - 10.1007/s00395-023-01011-3
DO - 10.1007/s00395-023-01011-3
M3 - Review article
C2 - 37775647
AN - SCOPUS:85172824972
SN - 1435-1803
VL - 118
SP - 39
JO - Basic research in cardiology
JF - Basic research in cardiology
IS - 1
ER -