Glutamina: Aspectos bioquímicos, metabólicos, moleculares e suplementação

Translated title of the contribution: Glutamine: Biochemical, metabolic, molecular aspects and supplementation

Vinicius Fernandes Cruzat, Éder Ricardo Petry, Julio Tirapegui

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)


Glutamine is the most frequent free amino acid in the serum and muscular tissue. Nutritionally, it is classified as a non-essential amino acid, once it can be synthesized by the body from other amino acids. Glutamine is involved in different functions, such as cell proliferation and development, basic acid balance, ammonia transportation between tissues, carbon skeleton donation to the gluconeogenesis, participation in the antioxidant system, among others. Molecular biology techniques show that it may also influence several cell signaling ways, especially the expression of heat shock proteins (HSP). The HSPs contribute to the maintenance of the cellular homeostasis in the presence of stress agents such as oxygen reactive species (ORE). In situations of high cellular catabolism, as after intense and prolonged physical exercises, the glutamine concentration may become reduced. Lower availability of this amino acid may decrease the cell resistance to injuries, leading to cellular apoptosis processes. Therefore, L-glutamine supplementation either in free form or as dipeptide has been investigated. Some biochemical and metabolic aspects, molecular mechanism of glutamine, as well as the effects of its supplementation are approached in the present article.

Translated title of the contributionGlutamine: Biochemical, metabolic, molecular aspects and supplementation
Original languagePortuguese
Pages (from-to)392-397
Number of pages6
JournalRevista Brasileira de Medicina do Esporte
Issue number5
Publication statusPublished - 1 Sept 2009
Externally publishedYes


  • Dipeptide
  • Exercise
  • Glutamine
  • HSP
  • Supplementation


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