Homocysteine is positively associated with cytokine IL-18 plasma levels in coronary artery bypass surgery patients

Craig Steven McLachlan, Wendy Chen Nee Chua, Peter Tsun Hon Wong, Lian Kah Ti, Christopher Chen, Reida Menshawe El Oakley

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9 Citations (Scopus)

Abstract

Homocysteine, cytokines (IL-18, IL-6, IL-8) are involved in vascular inflammation and coronary artery disease. Homocysteine influences endothelial IL-6 and IL-8 cytokine expression and release, however, an association between homocysteine and IL-18 has not been previously investigated in endothelial/smooth muscle cells and or in coronary artery disease. We report in 9 coronary artery bypass surgery (CABG) patients a positive correlation r=0.86 between homocysteine and IL-18 plasma levels (p<0.05). Plasma IL-18 levels are significantly higher in those patients with elevated homocysteine compared to those with normal levels (p<0.02; 153 ± 19 pg/ml versus 116 ± 14 pg/ml respectively). Our in vitro cell culture studies suggest that the source of IL-18 in CABG patients with elevated homocysteine is not from vascular smooth muscle or endothelial cells.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalBioFactors
Volume23
Issue number2
DOIs
Publication statusPublished - 1 Jan 2005
Externally publishedYes

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Keywords

  • CABG
  • Coronary artery disease
  • Homocysteine
  • Human coronary smooth muscle and endothelial cells
  • IL-18

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