Human Immunodeficiency Virus-Related Heart Disease

Friedrich Thienemann, Melinda Jane Carrington, Karen Sliwa, Mpiko Ntsekhe, Simon Stewart

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter describes the nexus between the underlying scourges of human immunodeficiency virus (HIV)/AIDS in communities such as Soweto and the range of related heart disease presentations. It presents a case study examining the Heart of Soweto registry in order to gain knowledge of the impact of HIV/AIDS on heart disease presentations in a typical African urban community at high risk of exposure to the virus. The study focuses on the potential impact of concurrently prescribed HAART. Pharmacological therapy most commonly comprised loop diuretics in addition to spironolactone, a beta blocker, an ACE inhibitor, aspirin, and digoxin. Immediately following the study period, the South African government initiated a national program of HAART application in those infected with HIV. As noted in the original report, this will have a mitigating effect on presentations of HIV-related CMO and pericardial effusion/pericarditis.

Original languageEnglish
Title of host publicationHeart of Africa
Subtitle of host publicationClinical Profile of an Evolving Burden of Heart Disease in Africa
Number of pages7
ISBN (Electronic)9781118336960
ISBN (Print)9781119097136
Publication statusPublished - 13 May 2016
Externally publishedYes


  • African urban community
  • AIDS
  • Heart disease
  • HIV
  • Pharmacological therapy


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