Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

Mina Elahy; Swati Baindur-Hudson; Vinicius F. Cruzat; Philip Newsholme; Crispin R. Dass

doi:10.1530/JOE-14-0065

Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

Mina Elahy, Swati Baindur-Hudson, Vinicius F. Cruzat, Philip Newsholme, Crispin R. Dass

Research output: Contribution to journal › Review article

48 Citations (Scopus)

Abstract

Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

Original language	English
Pages (from-to)	129-139
Number of pages	11
Journal	Journal of Endocrinology
Volume	222
Issue number	3
DOIs	https://doi.org/10.1530/JOE-14-0065
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

Diabetes
Oxidative stress
PEDF
Pericyte
Redox balance
Signal transduction

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abstract = "Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.",

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AU - Baindur-Hudson, Swati

AU - Cruzat, Vinicius F.

AU - Newsholme, Philip

AU - Dass, Crispin R.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

AB - Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

KW - Diabetes

KW - Oxidative stress

KW - PEDF

KW - Pericyte

KW - Redox balance

KW - Signal transduction

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Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

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Keywords

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