Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

Mina Elahy, Swati Baindur-Hudson, Vinicius F. Cruzat, Philip Newsholme, Crispin R. Dass

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalJournal of Endocrinology
Volume222
Issue number3
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Diabetes
  • Oxidative stress
  • PEDF
  • Pericyte
  • Redox balance
  • Signal transduction

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