Most individuals with treated blood pressures above target receive only one or two antihypertensive drug classes

D. J. Campbell, M. Mcgrady, D. L. Prior, J. M. Coller, U. Boffa, L. Shiel, D. Liew, R. Wolfe, S. Stewart, C. M. Reid, H. Krum

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Abstract

Background: A significant proportion of individuals taking antihypertensive therapies fail to achieve blood pressures <140/90mmHg. In order to develop strategies for improved treatment of blood pressure, we examined the association of blood pressure control with antihypertensive therapies and clinical and lifestyle factors in a cohort of adults at increased cardiovascular risk. Methods: A cross-sectional study of 3994 adults from Melbourne and Shepparton, Australia enrolled in the SCReening Evaluation of the Evolution of New Heart Failure (SCREEN-HF) study. Inclusion criteria were age ≥60 years with one or more of self-reported ischaemic or other heart disease, atrial fibrillation, cerebrovascular disease, renal impairment or treatment for hypertension or diabetes for ≥2 years. Exclusion criteria were known heart failure or cardiac abnormality on echocardiography or other imaging. The main outcome measures were the proportion of participants receiving antihypertensive therapy with blood pressures ≥140/90mmHg and the association of blood pressure control with antihypertensive therapies and clinical and lifestyle factors. Results: Of 3623 participants (1975 men and 1648 women) receiving antihypertensive therapy, 1867 (52%) had blood pressures ≥140/90mmHg. Of these 1867 participants, 1483 (79%) were receiving only one or two antihypertensive drug classes. Blood pressures ≥140/90mmHg were associated with increased age, male sex, waist circumference and log amino-terminal-pro-B-type natriuretic peptide levels. Conclusions: Most individuals with treated blood pressures above target receive only one or two antihypertensive drug classes. Prescribing additional antihypertensive drug classes and lifestyle modification may improve blood pressure control in this population of individuals at increased cardiovascular risk.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalInternal Medicine Journal
Volume43
Issue number2
DOIs
Publication statusPublished - 1 Feb 2013
Externally publishedYes

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Keywords

  • Blood pressure target
  • Cardiovascular risk
  • Hypertension
  • Medication
  • Population cohort

Cite this

Campbell, D. J., Mcgrady, M., Prior, D. L., Coller, J. M., Boffa, U., Shiel, L., Liew, D., Wolfe, R., Stewart, S., Reid, C. M., & Krum, H. (2013). Most individuals with treated blood pressures above target receive only one or two antihypertensive drug classes. Internal Medicine Journal, 43(2), 137-143. https://doi.org/10.1111/j.1445-5994.2012.02927.x