Palmitoylethanolamide (PEA) in the treatment of neuropathic pain: a case study

D. Kamper

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Neuropathic pain is a condition caused by a lesion or disease of the somatosensory nervous system. It may present as debilitating pain with a sensation of burning and electric-like symptoms and is often difficult to manage effectively. Although pharmacological medications are the first line of treatment, multidisciplinary teams are sometimes required to provide appropriate treatment to improve quality of life and overall wellbeing. Aim: The aim of this study is to present a case of post herpetic neuralgia relieved successfully by the compound palmitoylethanolamide (PEA) – a natural alternative to pharmacological pain relief. Methods: We present the case of a 67 year-old male with ongoing post-herpetic neuralgia, over a 3-year period, as a result of complications from shingles (herpes zoster). Previous studies on the relationship between PEA and neuropathy were reviewed, with an attempt to discuss the possible underlying mechanism of PEA on neuropathic pain. Results: PEA demonstrated effective pain relief within 48 hours at an administered daily dose of 900 mg (10 mg/kg). Conclusions: PEA may offer a valid nutraceutical treatment for practitioners. © The Author(s) 2021.
Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalNutrition and Health
Issue number2
Publication statusPublished - 2022


  • analgesic
  • CB2
  • neuropathy
  • palmitoylathenolamide
  • PEA
  • shingles
  • amide
  • ethanolamine derivative
  • palmidrol
  • palmitic acid derivative
  • aged
  • case report
  • complication
  • herpes zoster
  • human
  • male
  • neuralgia
  • pathology
  • pea
  • quality of life
  • Aged
  • Amides
  • Ethanolamines
  • Herpes Zoster
  • Humans
  • Male
  • Neuralgia
  • Palmitic Acids
  • Peas
  • Quality of Life


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