Passive transfer of demyelination by serum of IgG from chronic inflammatory demyelinating polyneuropathy patients

Wei Xing Yan, Jude Taylor, Susan Andrias-Kauba, John D. Pollard

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is regarded as an autoimmune disorder, but no clearly defined autoimmune mechanism has been described. Although most patients respond to plasma exchange, no convincing role for autoantibodies has yet been demonstrated. In this study, we have successfully passively transferred disease using sera and purified IgG from 4 of 12 patients responsive to plasma exchange by bypassing the blood-nerve barrier by intraneural injection or opening it by activated T cells. The sera from CIDP patients or purified IgG produced marked conduction block and demyelination, but normal sera or IgG or that from patients with multiple sclerosis or other neuropathies did not. These observations strongly support an important role for anti-myelin/Schwann cell autoantibodies in the pathogenesis of CIDP at least in some patients.

Original languageEnglish
Pages (from-to)765-775
Number of pages11
JournalAnnals of Neurology
Volume47
Issue number6
DOIs
Publication statusPublished - 30 Jun 2000
Externally publishedYes

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