Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats

Q. Wang, P. H. Wang, C. McLachlan, P. T.H. Wong

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Sprague-Dawley rats with unilateral lesion of the medial forebrain bundle by 6-hydroxydopamine showed marked decrease in the expression of dopamine D 1 and D2 receptors in the prefrontal cortex. Simvastatin (10 mg/kg/day for 4 weeks) restored receptor expression to control levels. Given the association of dopaminergic dysfunction in the prefrontal cortex and cognitive deficits in Parkinson's disease, these findings may have implication in the treatment of cognitive decline in advanced Parkinson's disease.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalBrain Research
Volume1045
Issue number1-2
DOIs
Publication statusPublished - 31 May 2005
Externally publishedYes

Keywords

  • 6-OHDA lesion
  • Dopamine D and D receptors
  • Downregulation
  • Parkinson's disease (PD)
  • Simvastatin, hydroxymethylglutaryl-coenzyme A reductase inhibitor
  • Upregulation

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