The CCK
                        2
                         agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat

J. M. Farook; C. S. McLachlan; Y. Z. Zhu; L. Lee; S. M. Moochhala; P. T.H. Wong

doi:10.1016/j.neulet.2003.11.010

The CCK ₂ agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat

J. M. Farook, C. S. McLachlan, Y. Z. Zhu, L. Lee, S. M. Moochhala, P. T.H. Wong

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Our previous studies (NeuroReport 12 (2001) 2717) showed that PVG hooded and not Sprague-Dawley (SD) rats exhibit remarkable freezing behavior on exposure to a cat in the cat freezing test apparatus. In the present study, we further examined the differences between these two strains of rats in response to repeated daily exposure to a cat in the cat freezing test apparatus. Freezing behavior habituation was observed in both PVG hooded (days 5-7) and SD rats (days 3-7). A selective CCK ₂ agonist (BC264, 0.3 μg/kg, i.p.) on day 8 reversed habituated freezing behavior and locomotor activity in PVG hooded rats, but not in SD rats. These results suggest that CCK ₂ receptors mediate habituation to an anxiety-inducing stimulus in PVG hooded rats and further suggest that differential expression of these CCK ₂ receptors underlies this strain difference.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	Neuroscience Letters
Volume	355
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2003.11.010
Publication status	Published - 30 Jan 2004
Externally published	Yes

Keywords

Behavior
Freezing
Habituation
PVG hooded and Sprague-Dawley
Rats

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10.1016/j.neulet.2003.11.010

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title = "The CCK 2 agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat",

abstract = " Our previous studies (NeuroReport 12 (2001) 2717) showed that PVG hooded and not Sprague-Dawley (SD) rats exhibit remarkable freezing behavior on exposure to a cat in the cat freezing test apparatus. In the present study, we further examined the differences between these two strains of rats in response to repeated daily exposure to a cat in the cat freezing test apparatus. Freezing behavior habituation was observed in both PVG hooded (days 5-7) and SD rats (days 3-7). A selective CCK 2 agonist (BC264, 0.3 μg/kg, i.p.) on day 8 reversed habituated freezing behavior and locomotor activity in PVG hooded rats, but not in SD rats. These results suggest that CCK 2 receptors mediate habituation to an anxiety-inducing stimulus in PVG hooded rats and further suggest that differential expression of these CCK 2 receptors underlies this strain difference.",

keywords = "Behavior, Freezing, Habituation, PVG hooded and Sprague-Dawley, Rats",

author = "Farook, {J. M.} and McLachlan, {C. S.} and Zhu, {Y. Z.} and L. Lee and Moochhala, {S. M.} and Wong, {P. T.H.}",

year = "2004",

month = jan,

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language = "English",

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journal = "Neuroscience Letters",

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AU - Farook, J. M.

AU - McLachlan, C. S.

AU - Zhu, Y. Z.

AU - Lee, L.

AU - Moochhala, S. M.

AU - Wong, P. T.H.

PY - 2004/1/30

Y1 - 2004/1/30

N2 - Our previous studies (NeuroReport 12 (2001) 2717) showed that PVG hooded and not Sprague-Dawley (SD) rats exhibit remarkable freezing behavior on exposure to a cat in the cat freezing test apparatus. In the present study, we further examined the differences between these two strains of rats in response to repeated daily exposure to a cat in the cat freezing test apparatus. Freezing behavior habituation was observed in both PVG hooded (days 5-7) and SD rats (days 3-7). A selective CCK 2 agonist (BC264, 0.3 μg/kg, i.p.) on day 8 reversed habituated freezing behavior and locomotor activity in PVG hooded rats, but not in SD rats. These results suggest that CCK 2 receptors mediate habituation to an anxiety-inducing stimulus in PVG hooded rats and further suggest that differential expression of these CCK 2 receptors underlies this strain difference.

AB - Our previous studies (NeuroReport 12 (2001) 2717) showed that PVG hooded and not Sprague-Dawley (SD) rats exhibit remarkable freezing behavior on exposure to a cat in the cat freezing test apparatus. In the present study, we further examined the differences between these two strains of rats in response to repeated daily exposure to a cat in the cat freezing test apparatus. Freezing behavior habituation was observed in both PVG hooded (days 5-7) and SD rats (days 3-7). A selective CCK 2 agonist (BC264, 0.3 μg/kg, i.p.) on day 8 reversed habituated freezing behavior and locomotor activity in PVG hooded rats, but not in SD rats. These results suggest that CCK 2 receptors mediate habituation to an anxiety-inducing stimulus in PVG hooded rats and further suggest that differential expression of these CCK 2 receptors underlies this strain difference.

KW - Behavior

KW - Freezing

KW - Habituation

KW - PVG hooded and Sprague-Dawley

KW - Rats

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SP - 205

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JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -

The CCK ₂ agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat

Abstract

Keywords

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