The CCK 2 agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat

J. M. Farook, C. S. McLachlan, Y. Z. Zhu, L. Lee, S. M. Moochhala, P. T.H. Wong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Our previous studies (NeuroReport 12 (2001) 2717) showed that PVG hooded and not Sprague-Dawley (SD) rats exhibit remarkable freezing behavior on exposure to a cat in the cat freezing test apparatus. In the present study, we further examined the differences between these two strains of rats in response to repeated daily exposure to a cat in the cat freezing test apparatus. Freezing behavior habituation was observed in both PVG hooded (days 5-7) and SD rats (days 3-7). A selective CCK 2 agonist (BC264, 0.3 μg/kg, i.p.) on day 8 reversed habituated freezing behavior and locomotor activity in PVG hooded rats, but not in SD rats. These results suggest that CCK 2 receptors mediate habituation to an anxiety-inducing stimulus in PVG hooded rats and further suggest that differential expression of these CCK 2 receptors underlies this strain difference.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalNeuroscience Letters
Volume355
Issue number3
DOIs
Publication statusPublished - 30 Jan 2004
Externally publishedYes

Keywords

  • Behavior
  • Freezing
  • Habituation
  • PVG hooded and Sprague-Dawley
  • Rats

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