Abstract
BC-264 a CCK2 agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30 μg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20 min cat exposure were calculated. At higher doses (15 or 30 μg/kg) but not lower doses (0.1-1 μg/kg) BC264 statistically significantly decreased freezing compared to control (p < 0.001).
Original language | English |
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Pages (from-to) | 808-809 |
Number of pages | 2 |
Journal | Peptides |
Volume | 30 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2009 |
Externally published | Yes |
Keywords
- CCK
- Predatory fear
- PVG hooded rat