The CCK2 agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat

Craig S. McLachlan; Justin M. Farook; Valérie Daugé; Peter T. Wong

doi:10.1016/j.peptides.2008.12.013

The CCK₂ agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat

Craig S. McLachlan, Justin M. Farook, Valérie Daugé, Peter T. Wong

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

BC-264 a CCK₂ agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30 μg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20 min cat exposure were calculated. At higher doses (15 or 30 μg/kg) but not lower doses (0.1-1 μg/kg) BC264 statistically significantly decreased freezing compared to control (p < 0.001).

Original language	English
Pages (from-to)	808-809
Number of pages	2
Journal	Peptides
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.peptides.2008.12.013
Publication status	Published - 1 Apr 2009
Externally published	Yes

Keywords

CCK
Predatory fear
PVG hooded rat

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title = "The CCK2 agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat",

abstract = "BC-264 a CCK2 agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30 μg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20 min cat exposure were calculated. At higher doses (15 or 30 μg/kg) but not lower doses (0.1-1 μg/kg) BC264 statistically significantly decreased freezing compared to control (p < 0.001).",

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AU - Daugé, Valérie

AU - Wong, Peter T.

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AB - BC-264 a CCK2 agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30 μg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20 min cat exposure were calculated. At higher doses (15 or 30 μg/kg) but not lower doses (0.1-1 μg/kg) BC264 statistically significantly decreased freezing compared to control (p < 0.001).

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KW - PVG hooded rat

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