Abstract
BC-264 a CCK2 agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30 μg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20 min cat exposure were calculated. At higher doses (15 or 30 μg/kg) but not lower doses (0.1-1 μg/kg) BC264 statistically significantly decreased freezing compared to control (p < 0.001).
| Original language | English |
|---|---|
| Pages (from-to) | 808-809 |
| Number of pages | 2 |
| Journal | Peptides |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Apr 2009 |
| Externally published | Yes |
Keywords
- CCK
- Predatory fear
- PVG hooded rat
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McLachlan, C. S., Farook, J. M., Daugé, V., & Wong, P. T. (2009). The CCK2 agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat. Peptides, 30(4), 808-809. https://doi.org/10.1016/j.peptides.2008.12.013