The CCK2 agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat

Craig S. McLachlan, Justin M. Farook, Valérie Daugé, Peter T. Wong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BC-264 a CCK2 agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30 μg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20 min cat exposure were calculated. At higher doses (15 or 30 μg/kg) but not lower doses (0.1-1 μg/kg) BC264 statistically significantly decreased freezing compared to control (p < 0.001).

Original languageEnglish
Pages (from-to)808-809
Number of pages2
JournalPeptides
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Apr 2009
Externally publishedYes

Keywords

  • CCK
  • Predatory fear
  • PVG hooded rat

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