The determinants of change in patella cartilage volume - A cohort study of healthy middle-aged women

S. P. Wijayaratne, A. J. Teichtahl, A. E. Wluka, F. Hanna, R. Bell, S. R. Davis, J. Adams, Flavia M. Cicuttini

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27 Citations (Scopus)

Abstract

Objectives. Although cartilage loss occurs with advancing age and is a hallmark of OA, the factors that affect cartilage change are not well established. The aim of this study was to explore the determinants of change in patella cartilage volume over 2 yrs among healthy middle-aged women with no clinical knee OA. Methods. One hundred and forty-eight women with no clinical knee OA were recruited from a previous population-based cross-sectional study of healthy women aged 40-67 yrs. MRI was performed at baseline and at 2 yrs, to assess patella cartilage and bone volume. Self-reported exercise was assessed by questionnaire. Results. Annual loss of patella cartilage volume was 1.6% (95% CI 1.2, 1.9). Age was positively associated with patella cartilage volume loss after adjustment for confounders (P = 0.05). For every 1 mm3 increase in patella bone volume at baseline, annual cartilage loss was reduced by 8.05 mm3 (95% CI 12.91, 3.19; P = 0.001). Fortnightly participation in exercise promoting an increased heart and respiratory rate for at least 20 min also tended to be associated with a reduced rate of patella cartilage volume loss (P = 0.09). Conclusion. Among middle-aged women with no clinical knee OA, advancing age expedites the rate of patella cartilage volume loss, while increased patella bone volume and exercise participation tends to be associated with a reduction in the rate of patella cartilage volume loss. Interventions targeting modifiable factors, such as physical activity, warrant further investigation as they may help to prevent patellofemoral OA.

Original languageEnglish
Pages (from-to)1426-1429
Number of pages4
JournalRheumatology
Volume47
Issue number9
DOIs
Publication statusPublished - 8 Sep 2008
Externally publishedYes

Keywords

  • Bone
  • Cartilage
  • Knee
  • Osteoarthritis
  • Patella

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    Wijayaratne, S. P., Teichtahl, A. J., Wluka, A. E., Hanna, F., Bell, R., Davis, S. R., Adams, J., & Cicuttini, F. M. (2008). The determinants of change in patella cartilage volume - A cohort study of healthy middle-aged women. Rheumatology, 47(9), 1426-1429. https://doi.org/10.1093/rheumatology/ken244