Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 233-247 |
| Number of pages | 15 |
| Journal | British Journal of Nutrition |
| Volume | 127 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2022 |
| Externally published | Yes |
Keywords
- Ascorbate
- Depletion
- Surgery
- Trauma
- Vitamin C
- anesthetic agent
- ascorbic acid
- local anesthetic agent
- vitamin
- abdominal aortic aneurysm
- abdominal surgery
- anterior cruciate ligament reconstruction
- aortic surgery
- ascorbic acid deficiency
- bariatric surgery
- bilateral salpingo-oophorectomy
- cardiopulmonary bypass
- cholecystectomy
- colon resection
- colorectal surgery
- coronary artery bypass graft
- elective surgery
- emergency surgery
- follow up
- gastrectomy
- gastrointestinal surgery
- hip arthroplasty
- hip surgery
- human
- hysterectomy
- laparoscopic surgery
- lung lobectomy
- meta analysis
- open heart surgery
- oral surgery
- orthopedic surgery
- pancreas surgery
- portocaval shunt
- postoperative complication
- postoperative period
- preoperative period
- Review
- Roux-en-Y gastric bypass
- spondylodesis
- subtotal pancreatic replacement
- surgical technique
- systematic review
- therapy effect
- total knee arthroplasty
- vagotomy
- vitamin blood level
- prospective study
- Ascorbic Acid
- Humans
- Prospective Studies
- Vitamins
Fingerprint
Dive into the research topics of 'The effects of surgery on plasma/serum vitamin C concentrations: A systematic review and meta-analysis: British Journal of Nutrition'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: British Journal of Nutrition, Vol. 127, No. 2, 2022, p. 233-247.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - The effects of surgery on plasma/serum vitamin C concentrations: A systematic review and meta-analysis
T2 - British Journal of Nutrition
AU - Travica, N.
AU - Ried, K.
AU - Hudson, I.
AU - Scholey, A.
AU - Pipingas, A.
AU - Sali, A.
N1 - Cited By :4 Export Date: 12 July 2022 CODEN: BJNUA Correspondence Address: Travica, N.; Centre for Human Psychopharmacology, Australia; email: [email protected] Chemicals/CAS: ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; Ascorbic Acid; Vitamins References: Carpenter, K.J., The discovery of Vitamin C (2012) Ann Nutr Metab, 61, pp. 259-264; Grollman, A.P., Lehninger, A.L., Enzymic synthesis of l -Ascorbic acid in different animal species (1957) Arch Biochem Biophys, 69, pp. 458-467; Kocot, J., Luchowska-Kocot, D., Kielczykowska, M., Does Vitamin C influence neurodegenerative diseases and psychiatric disorders? (2017) Nutrients, 9, p. 659; Rebouche, C.J., Ascorbic acid and carnitine biosynthesis (1991) Am J Clin Nutr, 54, pp. 1147S-1152S; Milne, D.B., Omaye, S.T., Effect of Vitamin C on copper and iron metabolism in the Guinea pig (1980) Int J Vitam Nutr Res, 50, pp. 301-308; Turley, S.D., West, C.E., Horton, B.J., The role of ascorbic acid in the regulation of cholesterol metabolism and in the pathogenesis of artherosclerosis (1976) Atherosclerosis, 24, pp. 1-18; Carr, A., Maggini, S., Vitamin C and immune function (2017) Nutrients, 9, p. 1211; Heuser, G., Vojdani, A., Enhancement of natural killer cell activity and T and B cell function by buffered Vitamin C in patients exposed to toxic chemicals: The role of protein kinase-C (1997) Immunopharmacol Immunotoxicol, 19, pp. 291-312; Harrison, F., Allard, J., Bixler, R., Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice (2009) Nutr Neurosci, 12, pp. 203-218; Travica, N., Ried, K., Sali, A., Vitamin C status and cognitive function: A systematic review (2017) Nutrients, 9, p. 960; Kónya, C., Ferdinandy, P., Vitamin C: New role of the old Vitamin in the cardiovascular system? (2006) Br J Pharmacol, 147, pp. 125-127; Marik, P.E., Vitamin C: An essential stress hormone during sepsis (2020) J Thorac Dis, 12 (SUPPL. 1), p. S84; Ravindran, P., Wiltshire, S., Das, K., Vitamin C deficiency in an Australian cohort of metropolitan surgical patients (2018) Pathology, 50, pp. 654-658; Hampl, J.S., Taylor, C.A., Johnston, C.S., Vitamin C deficiency and depletion in the United States: The third national health and nutrition examination survey, 1988 to 1994 (2004) Am J Public Health, 94, pp. 870-875; Spoelstra-De Man, A.M., Elbers, P.W., Oudemans-Van Straaten, H.M., Making sense of early high-dose intravenous Vitamin C in ischemia/reperfusion injury (2018) Crit Care, 22, p. 70; Delanghe, J.R., Langlois, M.R., De Buyzere, M.L., Vitamin C deficiency: More than just a nutritional disorder (2011) Genes Nutr, 6, pp. 341-346; Gariballa, S., Poor Vitamin C status is associated with increased depression symptoms following acute illness in older people (2014) Int J Vitam Nutr Res, 84, pp. 12-17; Lipner, S., A classic case of scurvy (2018) Lancet, 392, p. 431; Lim, D.J., Sharma, Y., Thompson, C.H., Vitamin C and alcohol: A call to action (2018) Bmj Nutr Prev Health, 1, p. 17; Brubacher, D., Moser, U., Jordan, P., Vitamin C concentrations in plasma as a function of intake: A meta-Analysis (2000) Int J Vitam Nutr Res, 70, pp. 226-237; Michels, K.B., Welch, A.A., Luben, R., Measurement of fruit and vegetable consumption with diet questionnaires and implications for analyses and interpretation (2005) Am J Epidemiol, 161, pp. 987-994; Carr, A.C., Shaw, G.M., Natarajan, R., Ascorbate-dependent vasopressor synthesis: A rationale for Vitamin C administration in severe sepsis and septic shock? (2015) Crit Care, 19, p. 418; Blee, T.H., Cogbill, T.H., Lambert, P.J., Hemorrhage associated with Vitamin C deficiency in surgical patients (2002) Surgery, 131, pp. 408-412; Carr, A.C., McCall, C., The role of Vitamin C in the treatment of pain: New insights (2017) J Transl Med, 15, p. 77; Mayland, C.R., Bennett, M.I., Allan, K., Vitamin C deficiency in cancer patients (2005) Palliat Med, 19, pp. 17-20; Dobson, G.P., Addressing the global burden of trauma in major surgery (2015) Front Surg, 2, p. 43; Daȩbrowska, A.M., Slotwiński, R., The immune response to surgery and infection (2014) Central Eur J Immunol, 39, pp. 532-537; Hollenberg, M., Mangano, D.T., Therapeutic approaches to postoperative ischemia. The Study of Perioperative Ischemia Research Group (1994) Am J Cardiol, 73, pp. 30b-33b; Giglio, M., Marucci, M., Testini, M., Goal-directed haemodynamic therapy and gastrointestinal complications in major surgery: A meta-Analysis of randomized controlled trials (2009) Br J Anaesth, 103, pp. 637-646; Drouin, G., Godin, J.-R., Pagé, B., The genetics of Vitamin C loss in vertebrates (2011) Curr Genomics, 12, pp. 371-378; Salah, D., Perioperative nutrition to enhance recovery after surgery (2016) Ain-Shams J Anaesthesiol, 9, p. 469; Bartlett, M.K., Jones, C.M., Ryan, A.E., Vitamin C studies on surgical patients (1940) Ann Surg, 111, p. 1; Crandon, J.H., Landau, B., Mikal, S., Ascorbic acid economy in surgical patients as indicated by blood ascorbic acid levels (1958) N Engl J Med, 258, pp. 105-113; Hill, A., Wendt, S., Benstoem, C., Vitamin C to improve organ dysfunction in cardiac surgery patients -Review and pragmatic approach (2018) Nutrients, 10, p. 974; Fukushima, R., Yamazaki, E., Vitamin C requirement in surgical patients (2010) Curr Opin Clin Nutr Metab Care, 13, pp. 669-676; Park, J., Lee, Y., Seo, H., Risk of bias assessment tool for non-randomized studies (RoBANS): Development and validation of a new instrument (2011) 19th Cochrane Colloquium; Kim, S.Y., Park, J.E., Lee, Y.J., Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity (2013) J Clin Epidemiol, 66, pp. 408-414; (2014) Computer Program. Version 5.3, , RevMan, The Nordic Cochrane Centre. The Cochrane Collaboration Copenhagen; Riley, R.D., Higgins, J.P., Deeks, J.J., Interpretation of random effects meta-Analyses (2011) Bmj, 342, p. d549; Santonocito, C., De Loecker, I., Donadello, K., C-reactive protein kinetics after major surgery (2014) Anesth Analg, 119, pp. 624-629; Bowyer, A., Royse, C.F., Postoperative recovery and outcomes-what are we measuring and for whom? (2016) Anaesthesia, 71, pp. 72-77; Higgins, J.P., Thomas, J., Chandler, J., (2019) Cochrane Handbook for Systematic Reviews of Interventions, , England: John Wiley & Sons; Behrend, H., Lengnick, H., Zdravkovic, V., Vitamin C demand is increased after total knee arthroplasty: A double-blind placebo-controlled-randomized study (2018) Knee Surg Sports Traumatol Arthrosc, 27, pp. 1-7; Cavarocchi, N.C., England, M.D., O'Brien, J.F., Superoxide generation during cardiopulmonary bypass: Is there a role for Vitamin E? (1986) J Surg Res, 40, pp. 519-527; Conway, F., Talwar, D., McMillan, D., The relationship between acute changes in the systemic inflammatory response and plasma ascorbic acid, alpha-Tocopherol and lipid peroxidation after elective hip arthroplasty (2015) Clin Nutr, 34, pp. 642-646; Lassnigg, A., Punz, A., Barker, R., Influence of intravenous Vitamin E supplementation in cardiac surgery on oxidative stress: A double-blinded, randomized, controlled study (2003) Br J Anaesth, 90, pp. 148-154; Louw, J.A., Werbeck, A., Louw, M.E., Blood Vitamin concentrations during the acute-phase response (1992) Crit Care Med, 20, pp. 934-941; Luo, M., Fernandez-Estivariz, C., Jones, D.P., Depletion of plasma antioxidants in surgical intensive care unit patients requiring parenteral feeding: Effects of parenteral nutrition with or without alanyl-glutamine dipeptide supplementation (2008) Nutrition, 24, pp. 37-44; Nanji, A., Freeman, J., Gastric by-pass surgery in morbidly obese patients markedly decreases serum levels of Vitamins A and C and iron in the peri-operative period (1985) Int J Obes, 9, pp. 177-179; Oktar, G., Sinci, V., Kalaycioǧlu, S., Biochemical and hemodynamic effects of ascorbic acid and alpha-Tocopherol in coronary artery surgery (2001) Scand J Clin Lab Invest, 61, pp. 621-629. , 10.1080/003655101753267982; Ozasa, H., Ishibashi, N., Ikeda, S., Clinical examination of the water-soluble Vitamin levels in blood during peripheral parenteral nutrition (2006) Kurume Med J, 53, pp. 79-87; Kaur, A., Negi, P., Sarna, V., The appraisement of antioxidant and oxidant status in women undergoing surgical menopause (2017) Indian J Clin Biochem, 32, pp. 179-185; Rodemeister, S., Duquesne, M., Adolph, M., Massive and long-lasting decrease in Vitamin C plasma levels as a consequence of extracorporeal circulation (2014) Nutrition, 30, pp. 673-678; Ruemelin, A., Doerr, S., Fauth, U., Single preoperative oral application of ascorbic acid does not affect postoperative plasma levels of ascorbic acid (2002) Ann Nutr Metab, 46, pp. 211-214; Schorah, C., Habibzadeh, N., Hancock, M., Changes in plasma and buffy layer Vitamin C concentrations following major surgery: What do they reflect? (1986) Ann Clin Biochem, 23, pp. 566-570; Vallance, S., Changes in plasma and buffy layer Vitamin C following surgery (1988) Br J Surg, 75, pp. 366-370; Valle-Giner, I., Marti-Bonmati, E., Alegria-Toran, A., Changes in alpha-Tocopherol and retinol levels during cardiopulmonary bypass correlate with maximal arterial partial pressure of oxygen (2007) Free Radic Res, 41, pp. 1061-1067; Yamazaki, E., Horikawa, M., Fukushima, R., Vitamin C supplementation in patients receiving peripheral parenteral nutrition after gastrointestinal surgery (2011) Nutrition, 27, pp. 435-439; Murphy, M.E., Kolvenbach, R., Aleksis, M., Antioxidant depletion in aortic crossclamping ischemia: Increase of the plasma α-Tocopheryl quinone/α-Tocopherol ratio (1992) Free Radic Biol Med, 13, pp. 95-100; Akita, S., Kawahara, M., Takeshita, T., Effect of general anesthesia on plasma ascorbic acid level (1987) Hiroshima J Med Sci, 36, pp. 69-73; McGinn, F., Hamilton, J.C., Ascorbic acid levels in stored blood and in patients undergoing surgery after blood transfusion (1976) Br J Surg, 63, pp. 505-507; Barker, T., Leonard, S.W., Trawick, R.H., Modulation of inflammation by Vitamin E and C supplementation prior to anterior cruciate ligament surgery (2009) Free Radic Biol Med, 46, pp. 599-606; Braga, M., Bissolati, M., Rocchetti, S., Oral preoperative antioxidants in pancreatic surgery: A double-blind, randomized, clinical trial (2012) Nutrition, 28, pp. 160-164; Fukushima, R., Koide, T., Yamazaki, E., P331 Water-soluble-vitamin status in the postoperative gastrointestinal surgical patients receiving peripheral parenteral nutrition (2009) Clin Nutr Suppl, 4, p. 164; Kleszczewski, T., Modzelewska, B., Lisowska, A., Levels of Vitamin C in the blood plasma patients treated with coronary artery bypass grafting increases significantly after surgery (2017) Biomed Pharmacother, 85, pp. 527-530; Ballmer, P.E., Reinhart, W.H., Jordan, P., Depletion of plasma Vitamin C but not of Vitamin E in response to cardiac operations (1994) J Thorac Cardiovasc Surg, 108, pp. 311-320; Nathens, A.B., Neff, M.J., Jurkovich, G.J., Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients (2002) Ann Surg, 236, p. 814; Netto, B.D.M., Moreira, E.A.M., Patiño, J.S.R., Influence of Roux-en-Y gastric bypass surgery on Vitamin C, myeloperoxidase, and oral clinical manifestations: A 2-year follow-up study (2012) Nutr Clin Pract, 27, pp. 114-121; Boesing, F., Moreira, E.A.M., Wilhelm-Filho, D., Roux-en-Y bypass gastroplasty: Markers of oxidative stress 6 months after surgery (2010) Obes Surg, 20, pp. 1236-1244; Van Stijn, M.F., Ligthart-Melis, G.C., Boelens, P.G., Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery (2008) World J Gastroenterol, 14, p. 6960; Hill, A., Borgs, C., Fitzner, C., Perioperative Vitamin C and E levels in cardiac surgery patients and their clinical significance (2019) Nutrients, 11, p. 2157; Jeon, Y., Park, J.S., Moon, S., Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial (2016) Pain Res Management, 2016, p. 9147279; Hill-Mündel, K., Schlegl, J., Biesalski, H.K., Preoperative ascorbic acid levels in proximal femur fracture patients have no postoperative clinical impact, while ascorbic acid levels upon discharge have a major effect on postoperative outcome (2019) J Clin Med, 9, p. 66; Chung, W.Y., Chung, J.K.O., Szeto, Y.T., Plasma ascorbic acid: Measurement, stability and clinical utility revisited (2001) Clin Biochem, 34, pp. 623-627; Travica, N., Ried, K., Sali, A., Plasma Vitamin C concentrations and cognitive function: A cross-sectional study (2019) Front Aging Neurosci, 11, p. 72; Kotzampassi, K., Kolios, G., Manousou, P., Oxidative stress due to anesthesia and surgical trauma: Importance of early enteral nutrition (2009) Mol Nutr Food Res, 53, pp. 770-779; Desborough, J., The stress response to trauma and surgery (2000) Br J Anaesth, 85, pp. 109-117; Sasazuki, S., Hayashi, T., Nakachi, K., Protective effect of Vitamin C on oxidative stress: A randomized controlled trial (2008) Int J Vitam Nutr Res, 78, pp. 121-128; Mezzetti, A., Lapenna, D., Romano, F., Systemic oxidative stress and its relationship with age and illness (1996) J Am Geriatr Soc, 44, pp. 823-827; Bikker, A., Wielders, J., Van Loo, R., Ascorbic acid deficiency impairs wound healing in surgical patients: Four case reports (2016) Int J Surg Open, 2, pp. 15-18; Travica, N., Ried, K., Pipingas, A., The effects of knee arthroplasty on plasma Vitamin C concentrations and cognitive function: A case study (2020) J Surg Case Rep, 2020, p. rjaa111; Sharma, Y., Miller, M., Shahi, R., Vitamin C deficiency in Australian hospitalised patients: An observational study (2019) Intern Med J, 49, pp. 189-196; Hornig, D., Distribution of ascorbic acid, metabolites and analogues in man and animals (1975) Ann N y Acad Sci, 258, pp. 103-118; Bergsten, P., Amitai, G., Kehrl, J., Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation (1990) J Biol Chem, 265, pp. 2584-2587; Avidan, M., Silvergleid, A.J., Hines, R., (2016) Surgical Blood Conservation: Intraoperative Hemodilution, , U: UpToDate, Kleinman S, Hines R, ur UpToDate [Internet] Waltham, MA: UpToDate; Ben-Poorat, S., Moridani, M., Laboratory investigation of Vitamin B 12 deficiency (2006) Lab Med, 37, pp. 166-174; Corpe, C.P., Eck, P., Wang, J., Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8 (2013) J Biol Chem, 288, pp. 9092-9101; Basu, T.K., Vitamin C-Aspirin interactions (1982) Int J Vitam Nutr Res Suppl, 23, pp. 83-90; Kirkland, L.L., Shaughnessy, E., Recognition and prevention of nosocomial malnutrition: A review and a call to action! (2017) Am Journal Medicine, 130, pp. 1345-1350; Avelino-Silva, T.J., Jaluul, O., Malnutrition in hospitalized older patients: Management strategies to improve patient care and clinical outcomes (2017) Int J Gerontol, 11, pp. 56-61; Armstrong, E., Jamieson, R., Porter, J., Food cooking methods contribute to the reduced Vitamin C content of foods prepared in hospitals and care facilities: A systematic review (2019) Int J Food Sci Tech, 54, pp. 291-299; Collie, J.T., Greaves, R.F., Jones, O.A., Vitamin C measurement in critical illness: Challenges, methodologies and quality improvements (2020) Clin Chem Lab Med (CCLM), 58, pp. 460-470; Kallner, A., Hartmann, D., Hornig, D., Steady-state turnover and body pool of ascorbic acid in man (1979) Am J Clin Nutr, 32, pp. 530-539; Noble, M., Healey, C.S., McDougal-Chukwumah, L.D., Old disease, new look? A first report of parkinsonism due to scurvy, and of refeeding-induced worsening of scurvy (2013) Psychosomatics, 54, pp. 277-283; Pullar, J.M., Bayer, S., Carr, A.C., Appropriate handling, processing and analysis of blood samples is essential to avoid oxidation of Vitamin C to dehydroascorbic acid (2018) Antioxidants, 7, p. 29; Travica, N., Ried, K., Hudson, I., The contribution of plasma and brain Vitamin C on age and gender-related cognitive differences: A mini-review of the literature (2020) Front Integr Neurosci, 14, p. 47; Norman, K., Pichard, C., Lochs, H., Prognostic impact of disease-related malnutrition (2008) Clin Nutr, 27, pp. 5-15
PY - 2022
Y1 - 2022
N2 - Vitamin C (ascorbic acid) is a water-soluble vitamin with an array of biological functions. A number of proposed factors contribute to the vitamin's plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/the magnitude and time frame of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 and April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre- and postoperatively were included into the meta-analysis. Data were grouped into short-term (≤7 d) and long-term (>7 d) postoperative follow-up. Twenty-three of thirty-one studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of -17·99 Amol/l (39 % depletion) (CI -22·81, -13·17) (trial arms = 25, n 565, P < 0·001) during the first postoperative week and -18·80 Amol/l (21 % depletion) (CI -25·04, -12·56) (trial arms = 6, n 166, P < 0·001) 2-3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery; however, high heterogeneity was observed amongst trials assessing concentration change during the first postoperative week. Overall, our results warrant larger, long-term investigations of changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology. © The Author(s) 2020.
AB - Vitamin C (ascorbic acid) is a water-soluble vitamin with an array of biological functions. A number of proposed factors contribute to the vitamin's plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/the magnitude and time frame of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 and April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre- and postoperatively were included into the meta-analysis. Data were grouped into short-term (≤7 d) and long-term (>7 d) postoperative follow-up. Twenty-three of thirty-one studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of -17·99 Amol/l (39 % depletion) (CI -22·81, -13·17) (trial arms = 25, n 565, P < 0·001) during the first postoperative week and -18·80 Amol/l (21 % depletion) (CI -25·04, -12·56) (trial arms = 6, n 166, P < 0·001) 2-3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery; however, high heterogeneity was observed amongst trials assessing concentration change during the first postoperative week. Overall, our results warrant larger, long-term investigations of changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology. © The Author(s) 2020.
KW - Ascorbate
KW - Depletion
KW - Surgery
KW - Trauma
KW - Vitamin C
KW - anesthetic agent
KW - ascorbic acid
KW - local anesthetic agent
KW - vitamin
KW - abdominal aortic aneurysm
KW - abdominal surgery
KW - anterior cruciate ligament reconstruction
KW - aortic surgery
KW - ascorbic acid deficiency
KW - bariatric surgery
KW - bilateral salpingo-oophorectomy
KW - cardiopulmonary bypass
KW - cholecystectomy
KW - colon resection
KW - colorectal surgery
KW - coronary artery bypass graft
KW - elective surgery
KW - emergency surgery
KW - follow up
KW - gastrectomy
KW - gastrointestinal surgery
KW - hip arthroplasty
KW - hip surgery
KW - human
KW - hysterectomy
KW - laparoscopic surgery
KW - lung lobectomy
KW - meta analysis
KW - open heart surgery
KW - oral surgery
KW - orthopedic surgery
KW - pancreas surgery
KW - portocaval shunt
KW - postoperative complication
KW - postoperative period
KW - preoperative period
KW - Review
KW - Roux-en-Y gastric bypass
KW - spondylodesis
KW - subtotal pancreatic replacement
KW - surgical technique
KW - systematic review
KW - therapy effect
KW - total knee arthroplasty
KW - vagotomy
KW - vitamin blood level
KW - prospective study
KW - Ascorbic Acid
KW - Humans
KW - Prospective Studies
KW - Vitamins
U2 - 10.1017/S0007114520004353
DO - 10.1017/S0007114520004353
M3 - Article
SN - 0007-1145
VL - 127
SP - 233
EP - 247
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 2
ER -