TY - JOUR
T1 - The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories
T2 - A Systematic Analysis for the Global Burden of Disease Study 2019
AU - Gupta, Bhawna
AU - Cunha, Amanda Ramos Da
AU - Compton, Kelly
AU - Xu, Rixing
AU - Mishra, Rashmi
AU - Drangsholt, Mark Thomas
AU - Antunes, Jose Leopoldo Ferreira
AU - Kerr, Alexander R.
AU - Acheson, Alistair R.
AU - Lu, Dan
AU - Wallace, Lindsey E.
AU - Kocarnik, Jonathan M.
AU - Fu, Weijia
AU - Dean, Frances E.
AU - Pennini, Alyssa
AU - Henrikson, Hannah Jacqueline
AU - Alam, Tahiya
AU - Ababneh, Emad
AU - Abd-Elsalam, Sherief
AU - Abdoun, Meriem
AU - Abidi, Hassan
AU - Abubaker Ali, Hiwa
AU - Abu-Gharbieh, Eman
AU - Adane, Tigist Demssew
AU - Addo, Isaac Yeboah
AU - Ahmad, Sajjad
AU - Ahmad, Sajjad
AU - Ahmed Rashid, Tarik
AU - Akonde, Maxwell
AU - Al Hamad, Hanadi
AU - Alahdab, Fares
AU - Alimohamadi, Yousef
AU - Alipour, Vahid
AU - Al-Maweri, Sadeq Ali
AU - Alsharif, Ubai
AU - Ansari-Moghaddam, Alireza
AU - Anwar, Sumadi Lukman
AU - Anyasodor, Anayochukwu Edward
AU - Arabloo, Jalal
AU - Aravkin, Aleksandr Y.
AU - Aruleba, Raphael Taiwo
AU - Asaad, Malke
AU - Ashraf, Tahira
AU - Athari, Seyyed Shamsadin
AU - Attia, Sameh
AU - Azadnajafabad, Sina
AU - Azangou-Khyavy, Mohammadreza
AU - Badar, Muhammad
AU - Baghcheghi, Nayereh
AU - Banach, Maciej
AU - Bardhan, Mainak
AU - Barqawi, Hiba Jawdat
AU - Bashir, Nasir Z.
AU - Bashiri, Azadeh
AU - Benzian, Habib
AU - Bernabe, Eduardo
AU - Bhagat, Devidas S.
AU - Bhojaraja, Vijayalakshmi S.
AU - Bjørge, Tone
AU - Bouaoud, Souad
AU - Braithwaite, Dejana
AU - Briko, Nikolay Ivanovich
AU - Calina, Daniela
AU - Carreras, Giulia
AU - Chakraborty, Promit Ananyo
AU - Chattu, Vijay Kumar
AU - Chaurasia, Akhilanand
AU - Chen, Meng Xuan
AU - Cho, William C.S.
AU - Chu, Dinh Toi
AU - Chukwu, Isaac Sunday
AU - Chung, Eunice
AU - Cruz-Martins, Natália
AU - Dadras, Omid
AU - Dai, Xiaochen
AU - Dandona, Lalit
AU - Dandona, Rakhi
AU - Daneshpajouhnejad, Parnaz
AU - Darvishi Cheshmeh Soltani, Reza
AU - Darwesh, Aso Mohammad
AU - Debela, Sisay Abebe
AU - Derbew Molla, Meseret
AU - Dessalegn, Fikadu Nugusu
AU - Dianati-Nasab, Mostafa
AU - Digesa, Lankamo Ena
AU - Dixit, Shilpi Gupta
AU - Dixit, Abhinav
AU - Djalalinia, Shirin
AU - El Sayed, Iman
AU - El Tantawi, Maha
AU - Enyew, Daniel Berhanie
AU - Erku, Daniel Asfaw
AU - Ezzeddini, Rana
AU - Fagbamigbe, Adeniyi Francis
AU - Falzone, Luca
AU - Fetensa, Getahun
AU - Fukumoto, Takeshi
AU - Gaewkhiew, Piyada
AU - Gallus, Silvano
AU - Gebrehiwot, Mesfin
AU - Ghashghaee, Ahmad
AU - Gill, Paramjit Singh
AU - Golechha, Mahaveer
AU - Goleij, Pouya
AU - Gomez, Ricardo Santiago
AU - Gorini, Giuseppe
AU - Guimaraes, Andre Luiz Sena
AU - Gupta, Bhawna
AU - Gupta, Sapna
AU - Gupta, Veer Bala
AU - Gupta, Vivek Kumar
AU - Haj-Mirzaian, Arvin
AU - Halboub, Esam S.
AU - Halwani, Rabih
AU - Hanif, Asif
AU - Hariyani, Ninuk
AU - Harorani, Mehdi
AU - Hasani, Hamidreza
AU - Hassan, Abbas M.
AU - Hassanipour, Soheil
AU - Hassen, Mohammed Bheser
AU - Hay, Simon I.
AU - Hayat, Khezar
AU - Herrera-Serna, Brenda Yuliana
AU - Holla, Ramesh
AU - Horita, Nobuyuki
AU - Hosseinzadeh, Mehdi
AU - Hussain, Salman
AU - Ilesanmi, Olayinka Stephen
AU - Ilic, Irena M.
AU - Ilic, Milena D.
AU - Isola, Gaetano
AU - Jaiswal, Abhishek
AU - Jani, Chinmay T.
AU - Javaheri, Tahereh
AU - Jayarajah, Umesh
AU - Jayaram, Shubha
AU - Joseph, Nitin
AU - Kadashetti, Vidya
AU - Kandaswamy, Eswar
AU - Karanth, Shama D.
AU - Karaye, Ibraheem M.
AU - Kauppila, Joonas H.
AU - Kaur, Harkiran
AU - Keykhaei, Mohammad
AU - Khader, Yousef Saleh
AU - Khajuria, Himanshu
AU - Khanali, Javad
AU - Khatib, Mahalaqua Nazli
AU - Khayat Kashani, Hamid Reza
AU - Khazeei Tabari, Mohammad Amin
AU - Kim, Min Seo
AU - Kompani, Farzad
AU - Koohestani, Hamid Reza
AU - Kumar, G. Anil
AU - Kurmi, Om P.
AU - La Vecchia, Carlo
AU - Lal, Dharmesh Kumar
AU - Landires, Iván
AU - Lasrado, Savita
AU - Ledda, Caterina
AU - Lee, Yo Han
AU - Libra, Massimo
AU - Lim, Stephen S.
AU - Listl, Stefan
AU - Lopukhov, Platon D.
AU - Mafi, Ahmad R.
AU - Mahumud, Rashidul Alam
AU - Malik, Ahmad Azam
AU - Mathur, Manu Raj
AU - Maulud, Sazan Qadir
AU - Meena, Jitendra Kumar
AU - Mehrabi Nasab, Entezar
AU - Mestrovic, Tomislav
AU - Mirfakhraie, Reza
AU - Misganaw, Awoke
AU - Misra, Sanjeev
AU - Mithra, Prasanna
AU - Mohammad, Yousef
AU - Mohammadi, Mokhtar
AU - Mohammadi, Esmaeil
AU - Mokdad, Ali H.
AU - Moni, Mohammad Ali
AU - Moraga, Paula
AU - Morrison, Shane Douglas
AU - Mozaffari, Hamid Reza
AU - Mubarik, Sumaira
AU - Murray, Christopher J.L.
AU - Nair, Tapas Sadasivan
AU - Narasimha Swamy, Sreenivas
AU - Narayana, Aparna Ichalangod
AU - Nassereldine, Hasan
AU - Natto, Zuhair S.
AU - Nayak, Biswa Prakash
AU - Negru, Serban Mircea
AU - Nggada, Haruna Asura
AU - Nouraei, Hasti
AU - Nuñez-Samudio, Virginia
AU - Oancea, Bogdan
AU - Olagunju, Andrew T.
AU - Omar Bali, Ahmed
AU - Padron-Monedero, Alicia
AU - Padubidri, Jagadish Rao
AU - Pandey, Anamika
AU - Pardhan, Shahina
AU - Patel, Jay
AU - Pezzani, Raffaele
AU - Piracha, Zahra Zahid
AU - Rabiee, Navid
AU - Radhakrishnan, Venkatraman
AU - Radhakrishnan, Raghu Anekal
AU - Rahmani, Amir Masoud
AU - Rahmanian, Vahid
AU - Rao, Chythra R.
AU - Rao, Sowmya J.
AU - Rath, Goura Kishor
AU - Rawaf, David Laith
AU - Rawaf, Salman
AU - Rawassizadeh, Reza
AU - Razeghinia, Mohammad Sadegh
AU - Rezaei, Nima
AU - Rezaei, Negar
AU - Rezaei, Nima
AU - Rezapour, Aziz
AU - Riad, Abanoub
AU - Roberts, Thomas J.
AU - Romero-Rodríguez, Esperanza
AU - Roshandel, Gholamreza
AU - Manjula, S.
AU - Chandan, S. N.
AU - Saddik, Basema
AU - Saeb, Mohammad Reza
AU - Saeed, Umar
AU - Safaei, Mohsen
AU - Sahebazzamani, Maryam
AU - Sahebkar, Amirhossein
AU - Salek Farrokhi, Amir
AU - Samy, Abdallah M.
AU - Santric-Milicevic, Milena M.
AU - Sathian, Brijesh
AU - Satpathy, Maheswar
AU - Šekerija, Mario
AU - Senthilkumaran, Subramanian
AU - Seylani, Allen
AU - Shafaat, Omid
AU - Shahsavari, Hamid R.
AU - Shamsoddin, Erfan
AU - Sharew, Mequannent Melaku
AU - Sharifi-Rad, Javad
AU - Shetty, Jeevan K.
AU - Shivakumar, K. M.
N1 - Publisher Copyright:
© 2023 American Medical Association. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370000 (95% uncertainty interval [UI], 338000-401000) cases and 199000 (95% UI, 181000-217000) deaths for LOC and 167000 (95% UI, 153000-180000) cases and 114000 (95% UI, 103000-126000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts..
AB - Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370000 (95% uncertainty interval [UI], 338000-401000) cases and 199000 (95% UI, 181000-217000) deaths for LOC and 167000 (95% UI, 153000-180000) cases and 114000 (95% UI, 103000-126000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts..
UR - http://www.scopus.com/inward/record.url?scp=85174335406&partnerID=8YFLogxK
U2 - 10.1001/jamaoncol.2023.2960
DO - 10.1001/jamaoncol.2023.2960
M3 - Article
C2 - 37676656
AN - SCOPUS:85174335406
SN - 2374-2437
JO - JAMA Oncology
JF - JAMA Oncology
ER -