The thrombotic profile of treatment-naive HIV-positive black South Africans with acute coronary syndromes

A. C. Becker, B. Jacobson, S. Singh, K. Sliwa, S. Stewart, E. Libhaber, M. R. Essop

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Abstract

Background: Patients with human immunodeficiency virus (HIV) infection on protease inhibitors (PIs) have a heightened risk of arterial thrombosis but little is known about treatment-naive patients. Methods/Results: Prospective study from South Africa comparing thrombotic profiles of HIV-positive and -negative patients with acute coronary syndrome (ACS). A total of 30 treatment-naive HIV-positive patients with ACS were compared to 30 HIV-negative patients with ACS. Patients with HIV were younger; and besides smoking (73% vs 33%) and low high-density lipoprotein (HDL; 0.8 ± 0.3 vs 1.1 ± 0.4), they had fewer risk factors. Thrombophilia was more common in HIV-positive patients with lower protein C (PC; 82 ± 22 vs 108 ± 20) and higher factor VIII levels (201 ± 87 vs 136 ± 45). Patients with HIV had higher frequencies of anticardiolipin (aCL; 47% vs 10%) and antiprothrombin antibodies (87% vs 21%). Conclusion: Treatment-naive HIV-positive patients with ACS are younger, with fewer traditional risk factors but a greater degree of thrombophilia compared with HIV-negative patients.

Original languageEnglish
Pages (from-to)264-272
Number of pages9
JournalClinical and Applied Thrombosis/Hemostasis
Volume17
Issue number3
DOIs
Publication statusPublished - 1 Jun 2011
Externally publishedYes

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Keywords

  • acute coronary syndromes
  • blood coagulation factors
  • clinical thrombophilia
  • hypercoagulability
  • thrombophilia
  • thrombosis

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